Department of Laboratory Medicine, Fujian Key Laboratory of Laboratory Medicine, Gene Diagnosis Research Center, Fujian Clinical Research Center for Clinical Immunology Laboratory Test, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Department of Laboratory Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Front Immunol. 2024 Jul 3;15:1406671. doi: 10.3389/fimmu.2024.1406671. eCollection 2024.
We aimed to investigate the association and diagnostic value of monocyte distribution width (MDW) for chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC).
MDW levels were measured in 483 individuals (103 CHB, 77 LC, 153 HCC, and 150 controls). MDW was detected using UniCel Dx900 for specific cell volume parameters and the distribution of cell volumes.
Our findings revealed a dynamic upward change in MDW levels across different stages of chronic liver disease, from CHB to LC and HCC. In CHB, MDW levels were highest among HBeAg-positive CHB patients and exhibited a negative correlation with HBV markers while positively correlating with ALT levels. In LC, MDW showed a positive association with the pathological progression of LC, demonstrating consistency with CP scores. MDW proved to be equally effective as traditional detection for diagnosing LC. In HCC, MDW was positively correlated with HCC occurrence and development, with higher levels observed in the high MDW group, which also exhibited elevated AFP levels, MELD scores, and 90-day mortality rates. MDW surpassed predictive models in its effectiveness for diagnosing HCC, as well as CHB and LC, with respective areas under the curve of 0.882, 0.978, and 0.973. Furthermore, MDW emerged as an independent predictor of HCC.
MDW holds significant diagnostic efficacy in identifying CHB, LC, and HCC. These findings suggest that MDW could serve as a promising biomarker for predicting the severity of liver diseases and aid in rational clinical treatment strategies.
本研究旨在探讨单核细胞分布宽度（MDW）与慢性乙型肝炎（CHB）、肝硬化（LC）和肝细胞癌（HCC）的相关性及其诊断价值。
对 483 例个体（103 例 CHB、77 例 LC、153 例 HCC 和 150 例对照）进行 MDW 水平检测。采用 UniCel Dx900 检测特定细胞体积参数和细胞体积分布，以检测 MDW。
我们的研究结果显示，MDW 水平在慢性肝病的不同阶段呈动态上升趋势，从 CHB 到 LC 和 HCC。在 CHB 中，HBeAg 阳性 CHB 患者的 MDW 水平最高，与 HBV 标志物呈负相关，与 ALT 水平呈正相关。在 LC 中，MDW 与 LC 的病理进展呈正相关，与 CP 评分一致。MDW 在诊断 LC 方面与传统检测同样有效。在 HCC 中，MDW 与 HCC 的发生和发展呈正相关，高水平见于 MDW 高组，该组 AFP 水平、MELD 评分和 90 天死亡率均升高。MDW 在诊断 HCC 方面优于预测模型，对 CHB 和 LC 的诊断效能分别为 0.882、0.978 和 0.973。此外，MDW 是 HCC 的独立预测因子。
MDW 对 CHB、LC 和 HCC 的诊断具有重要的诊断效能。这些发现表明 MDW 可能成为预测肝脏疾病严重程度和指导合理临床治疗策略的有前途的生物标志物。
