Mori N, Oka K, Sakuma H, Tsunoda R, Kojima M
Cancer. 1985 Dec 1;56(11):2605-11. doi: 10.1002/1097-0142(19851201)56:11<2605::aid-cncr2820561112>3.0.co;2-2.
Seven patients with Hodgkin's disease were studied for the presence of lysozyme and alpha-1-antitrypsin activity by immunoelectron microscopy. As a result, Reed-Sternberg cells, Hodgkin's cells, and atypical cells were distinctly positive for lysozyme in four cases and weakly positive in the remaining three cases. These cells were also positive for alpha-1-antitrypsin in all cases. Because the cells of the monocyte-macrophage lineage also bore lysozyme and alpha-1-antitrypsin, it is suggested that Reed-Sternberg cells, Hodgkin's cells, and the atypical cells are derived from the monocyte-macrophage lineage.