Hansen N E, Clausen P P, Karle H, Christoffersen P
Scand J Haematol. 1981 Sep;27(3):186-92. doi: 10.1111/j.1600-0609.1981.tb00471.x.
Lysozyme positivity in lymph nodes from 33 patients with Hodgkin's disease was examined with an immunoperoxidase technique. Positive reactive histiocytes were found in 18 cases; in 7 cases lysozyme was found also in mononuclear Hodgkin cells and in 3 cases in both reactive histiocytes, mononuclear Hodgkin cells and Reed-Sternberg cells. There was no clear-cut correlation between cellular lysozyme positivity and such feature as histological type, clinical stage and plasma lysozyme. The findings support the theory that the malignant cell in Hodgkin's disease is derived from a lysozyme producing macrophage. The finding that lysozyme positivity was an inconstant feature may reflect both varying functional status of the macrophages and varying differentiation of Hodgkin cells. Increased plasma lysozyme in Hodgkin's disease may stem from both reactive histiocytes, mononuclear Hodgkin cells and Reed-Sternberg cells, but the major part is probably contributed by reactive histiocytes.
采用免疫过氧化物酶技术检测了33例霍奇金病患者淋巴结中的溶菌酶阳性情况。18例发现有阳性反应性组织细胞；7例在单核霍奇金细胞中也发现了溶菌酶，3例在反应性组织细胞、单核霍奇金细胞和里-施细胞中均发现了溶菌酶。细胞溶菌酶阳性与组织学类型、临床分期及血浆溶菌酶等特征之间没有明确的相关性。这些发现支持了霍奇金病中的恶性细胞来源于产生溶菌酶的巨噬细胞这一理论。溶菌酶阳性是一个不稳定特征这一发现可能既反映了巨噬细胞功能状态的变化，也反映了霍奇金细胞分化的不同。霍奇金病中血浆溶菌酶升高可能源于反应性组织细胞、单核霍奇金细胞和里-施细胞，但主要部分可能由反应性组织细胞产生。
