Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China; Translational Medicine Institute, Affiliated Tianjin Union Medical Center of Nankai University, Nankai University, Tianjin 300071, China.
Cancer Lett. 2024 Aug 28;598:217115. doi: 10.1016/j.canlet.2024.217115. Epub 2024 Jul 16.
Gut microbiota contributes to the homeostasis of immune system and is related to various diseases such as tumorigenesis. Ferroptosis, a new type of cell death, is also involved in the disease pathogenesis. Recent studies have found the correlations of gut microbiota mediated ferroptosis and immune cell death. Gut microbiota derived immunosuppressive metabolites, which can promote differentiation and function of immune cells, tend to inhibit ferroptosis through their receptors, whereas inflammatory metabolites from gut microbiota also affect the differentiation and function of immune cells and their ferroptosis. Thus, it is possible for gut microbiota to regulate immune cell ferroptosis. Indeed, gut microbiota metabolite receptor aryl hydrocarbon receptor (AhR) can affect ferroptosis of intestinal intraepithelial lymphocytes, leading to disease pathogenesis. Since immune cell ferroptosis in tumor microenvironment (TME) affects the occurrence and development of tumor, the modulation of gut microbiota in these cell ferroptosis might influence on the tumorigenesis, and also immunotherapy against tumors. Here we will summarize the recent advance of ferroptosis mediated by gut microbiota metabolites, which potentially acts as regulator(s) on immune cells in TME for therapy against tumor.
肠道微生物群有助于免疫系统的稳态，与肿瘤发生等各种疾病有关。铁死亡是一种新型的细胞死亡方式，也参与了疾病的发病机制。最近的研究发现了肠道微生物群介导的铁死亡与免疫细胞死亡的相关性。肠道微生物群衍生的免疫抑制代谢物可以促进免疫细胞的分化和功能，它们通过其受体倾向于抑制铁死亡，而来自肠道微生物群的炎症代谢物也影响免疫细胞的分化和功能及其铁死亡。因此，肠道微生物群有可能调节免疫细胞的铁死亡。事实上，肠道微生物群代谢物受体芳烃受体 (AhR) 可以影响肠道上皮内淋巴细胞的铁死亡，从而导致疾病发病机制。由于肿瘤微环境 (TME) 中的免疫细胞铁死亡会影响肿瘤的发生和发展，因此调节这些细胞铁死亡的肠道微生物群可能会影响肿瘤的发生，以及针对肿瘤的免疫治疗。在这里，我们将总结肠道微生物群代谢物介导的铁死亡的最新进展，这些进展可能作为 TME 中免疫细胞的调节剂，用于肿瘤治疗。
