Wang Shouliang, Li Shun, Zhang Mengli, Liu Ruihan, Ye Xigang, Mao Siyi, Yu Jianwu, Xie Xinhua, Tan Weige
Guangzhou Medical University, Guangzhou 511436, China.
Department of Breast Surgery, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Research (Wash D C). 2025 Jun 24;8:0744. doi: 10.34133/research.0744. eCollection 2025.
Cancer immunotherapy has greatly changed the therapeutic landscape for metastatic malignancies. Nevertheless, due to immune-related adverse events, drug resistance, and other factors, cancer immunotherapy remains largely untapped. Recent research has shown that the microbiota is crucial in shaping immune function and that its modulation can influence antitumor immunity. However, because of the intricate nature of the microbiome and immune system, a comprehensive mechanistic framework for understanding how the microbiota influences antitumor immune responses is still lacking. In this review, we summarize the mechanisms of the microbiota in antitumor immunity. We also comprehensively outline the methods for measuring the microbiota and their limitations. Additionally, we discuss the key challenges facing the targeting of the microbiota as a regulatory strategy for cancer immunotherapy.
癌症免疫疗法极大地改变了转移性恶性肿瘤的治疗格局。然而，由于免疫相关不良事件、耐药性和其他因素，癌症免疫疗法在很大程度上仍未得到充分利用。最近的研究表明，微生物群在塑造免疫功能方面至关重要，其调节可影响抗肿瘤免疫。然而，由于微生物组和免疫系统的复杂性，仍缺乏一个全面的机制框架来理解微生物群如何影响抗肿瘤免疫反应。在这篇综述中，我们总结了微生物群在抗肿瘤免疫中的机制。我们还全面概述了测量微生物群的方法及其局限性。此外，我们讨论了将微生物群作为癌症免疫疗法的一种调节策略所面临的关键挑战。
