Sun Yu, Kong Deyang, Zhang Qi, Xiang Renshen, Lu Shuaibing, Feng Lin, Zhang Haizeng
State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Clin Transl Oncol. 2025 Feb;27(2):439-448. doi: 10.1007/s12094-024-03601-6. Epub 2024 Jul 18.
Colorectal cancer is one of the most common cancers worldwide. Lymph node metastasis is an important marker of colorectal cancer progression and plays a key role in the evaluation of patient prognosis. Accurate preoperative assessment of lymph node metastasis is crucial for devising appropriate treatment plans. However, current clinical imaging methods have limitations in many aspects. Therefore, the discovery of a method for accurately predicting lymph node metastasis is crucial clinical decision-making. DNA methylation is a common epigenetic modification that can regulate gene expression, which also has an important impact on the development of colorectal cancer. It is considered to be a promising biomarker with good specificity and stability and has promising application in predicting lymph node metastasis in patients with colorectal cancer. This article reviews the characteristics and limitations of currently available methods for predicting lymph node metastasis in patients with colorectal cancer and discusses the role of DNA methylation as a biomarker.
结直肠癌是全球最常见的癌症之一。淋巴结转移是结直肠癌进展的重要标志，在评估患者预后中起关键作用。术前准确评估淋巴结转移对于制定合适的治疗方案至关重要。然而，目前的临床成像方法在许多方面存在局限性。因此，发现一种准确预测淋巴结转移的方法对临床决策至关重要。DNA甲基化是一种常见的表观遗传修饰，可调节基因表达，其对结直肠癌的发生发展也有重要影响。它被认为是一种具有良好特异性和稳定性的有前景的生物标志物，在预测结直肠癌患者淋巴结转移方面具有广阔的应用前景。本文综述了目前用于预测结直肠癌患者淋巴结转移的方法的特点和局限性，并探讨了DNA甲基化作为生物标志物的作用。
