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利福布汀在结核性脑膜炎兔模型中的中枢神经系统浓度。

Rifabutin central nervous system concentrations in a rabbit model of tuberculous meningitis.

机构信息

Institute for Infection and Immunity, St. George's, University of London, London, United Kingdom.

Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

出版信息

Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0078324. doi: 10.1128/aac.00783-24. Epub 2024 Jul 19.

DOI:10.1128/aac.00783-24
PMID:39028192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11304741/
Abstract

Tuberculous meningitis (TBM) has a high mortality, possibly due to suboptimal therapy. Drug exposure data of antituberculosis agents in the central nervous system (CNS) are required to develop more effective regimens. Rifabutin is a rifamycin equivalently potent to rifampin in human pulmonary tuberculosis. Here, we show that human-equivalent doses of rifabutin achieved potentially therapeutic exposure in relevant CNS tissues in a rabbit model of TBM, supporting further evaluation in clinical trials.

摘要

结核性脑膜炎（TBM）死亡率高，可能是由于治疗不充分。需要了解抗结核药物在中枢神经系统（CNS）中的药物暴露数据，以制定更有效的治疗方案。利福布汀在人类肺结核中的效力与利福平相当。在这里，我们在 TBM 的兔模型中表明，人等效剂量的利福布汀可在相关 CNS 组织中达到潜在的治疗性暴露，支持进一步在临床试验中进行评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3e/11304741/2cc2251eacd0/aac.00783-24.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3e/11304741/57f0f07e4318/aac.00783-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3e/11304741/2cc2251eacd0/aac.00783-24.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3e/11304741/57f0f07e4318/aac.00783-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3e/11304741/2cc2251eacd0/aac.00783-24.f002.jpg

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Arch Toxicol. 2023 Aug;97(8):2219-2230. doi: 10.1007/s00204-023-03531-2. Epub 2023 Jun 7.
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