Tau Rocio Lucia, Marandino Ana Eugenia, Panzera Yanina, Alamos Florencia, Vissani Maria Aldana, Romera Sonia Alejandra, Pérez Ruben, Maidana Silvina Soledad
Institute of Virology and Technological Innovations, Dr Nicolas Repetto and De losReseros, IVIT (INTA-CONICET), 1686, Hurlingham, Buenos Aires, Argentina.
Evolutionary Genetics Section, Faculty of Sciences, Institute of Biology, University of the Republic, Montevideo, Uruguay.
Virus Genes. 2024 Oct;60(5):559-562. doi: 10.1007/s11262-024-02093-4. Epub 2024 Jul 19.
The Equid alphaherpesvirus type 1 (EHV-1) infection can have devastating economic consequences in the horse industry due to large-scale outbreaks of abortions, perinatal foal mortality, and myeloencephalopathy. The present study analyzed the genome of two isolates obtained from aborted fetuses in Argentina, E/745/99 and E/1297/07. The E745/99 genome shares 98.2% sequence identity with Ab4, a reference EHV-1 strain. The E/1297/07 genome shares 99.8% identity with NY03, a recombinant strain containing part of ORF64 and part of the intergenic region from Equid alphaherpesvirus-4 (EHV-4). The E/1297/07 genome has the same breakpoints as other United States and Japanese recombinants, including NY03. The recombinant regions have varying numbers of tandem repeat sequences and different minor parental sequences (EHV-4), suggesting distinct origins of the recombinant events. These are the first complete genomes of EHV-1 from Argentina and South America available in the Databases.
1型马α疱疹病毒（EHV-1）感染可因大规模流产、围产期马驹死亡和脑脊髓炎而给养马业带来毁灭性的经济后果。本研究分析了从阿根廷流产胎儿中分离得到的两株病毒E/745/99和E/1297/07的基因组。E745/99基因组与参考EHV-1毒株Ab4的序列同一性为98.2%。E/1297/07基因组与NY03的同一性为99.8%，NY03是一种重组毒株，包含部分来自4型马α疱疹病毒（EHV-4）的开放阅读框64和部分基因间区域。E/1297/07基因组与其他美国和日本的重组毒株（包括NY03）具有相同的断点。重组区域具有不同数量的串联重复序列和不同的次要亲本序列（EHV-4），表明重组事件的起源不同。这些是数据库中可获得的来自阿根廷和南美的EHV-1的首批完整基因组。
