Faculty of Paramedical Science (Microbiology), Assam down town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, Assam 781026, India.
Department of Chemistry, School of Engineering and Technology, Dhanalakshmi Srinivasan University, Tiruchirappalli, Tamil Nadu 621112, India.
J Microbiol Methods. 2024 Apr;219:106907. doi: 10.1016/j.mimet.2024.106907. Epub 2024 Feb 20.
From the prehistoric period, the utilization of pigments as colouring agents was an integral part of human life. Early people may have utilized paint for aesthetic motives, according to archaeologists. The pigments are either naturally derived or synthesized in the laboratory. Different studies reported that certain synthetic colouring compounds were toxic and had adverse health and environmental effects. Therefore, knowing the drawbacks of these synthetic colouring agents now scientists are attracted towards the harmless natural pigments. The main sources of natural pigments are plants, animals or microorganisms. Out of these natural pigments, microorganisms are the most important source for the production and application of bioactive secondary metabolites. Among all kinds of microorganisms, bacteria have specific benefits due to their short life cycle, low sensitivity to seasonal and climatic variations, ease of scaling, and ability to create pigments of various colours. Based on these physical characteristics, bacterial pigments appear to be a promising sector for novel biotechnological applications, ranging from functional food production to the development of new pharmaceuticals and biomedical therapies. This review summarizes the need for bacterial pigments, biosynthetic pathways of carotenoids and different applications of bacterial pigments.
从史前时期开始,颜料作为着色剂的使用就是人类生活的一个组成部分。根据考古学家的说法,早期的人们可能出于审美动机而使用颜料。这些颜料要么是天然衍生的,要么是在实验室中合成的。不同的研究报告称,某些合成着色化合物具有毒性,会对健康和环境产生不利影响。因此,了解这些合成着色剂的缺点后,现在科学家们开始倾向于使用无害的天然色素。天然色素的主要来源是植物、动物或微生物。在这些天然色素中,微生物是生产和应用生物活性次生代谢产物的最重要来源。在所有种类的微生物中,由于细菌具有生命周期短、对季节性和气候变化不敏感、易于规模化以及能够产生各种颜色的色素等特点,因此具有特殊的优势。基于这些物理特性,细菌色素似乎是一个有前途的新型生物技术应用领域,涵盖了从功能性食品生产到新药物和生物医学疗法的开发。本综述总结了细菌色素的需求、类胡萝卜素的生物合成途径以及细菌色素的不同应用。