Department of Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New York, USA.
Physiol Rep. 2024 Jun;12(12):e16120. doi: 10.14814/phy2.16120.
Wildfire smoke (WFS) is an urgent and rapidly growing threat to global health. Aside from obvious threats to pulmonary function, increases in cardiac abnormalities or myocardial infarction have been documented during WF season, but little is known about the effects of WFS on cardiovascular health. We investigated the effect of nonoccupational WFS exposure on cardiovascular and pulmonary function at rest and during graded handgrip exercise through a case series of young, healthy adults (n = 4, 25 ± 6 years) assessed after ≥3 days of bad or good air quality. Peripheral and estimated central blood pressures, vascular stiffness, and microvascular function (Near infrared spectroscopy, NIRS) were assessed at rest, and during rhythmic handgrip exercise. WFS did not appear to alter resting peripheral, central BP, or vascular stiffness (all, p > 0.05). Slope 1 and slope 2 from the NIRS-vascular occlusion test (NIRS-VOT) were not different between conditions (p > 0.05). The change in SmO during exercise was lower (p = 0.02, = 0.62) with bad air quality. These preliminary findings suggest modest effects of environmental WFS exposure on muscle microvascular function during exercise in healthy adults. Future work is needed to elucidate the physiological changes with WFS exposure and the increased risk of cardiovascular events, perhaps exacerbated through physical activity.
野火烟雾（WFS）是对全球健康的一个紧迫且快速增长的威胁。除了对肺功能的明显威胁外，在 WF 季节期间已经记录到心脏异常或心肌梗死的增加，但对于 WFS 对心血管健康的影响知之甚少。我们通过对≥3 天空气质量差或好的年轻健康成年人（n=4，25±6 岁）进行病例系列研究，调查了非职业性 WFS 暴露对心血管和肺功能在休息和分级握力运动期间的影响。在休息时以及进行节奏性握力运动期间，评估了外周和估计的中心血压、血管僵硬和微血管功能（近红外光谱，NIRS）。WFS 似乎没有改变休息时的外周、中心血压或血管僵硬（均，p>0.05）。NIRS 血管闭塞试验（NIRS-VOT）的斜率 1 和斜率 2 在两种情况下没有差异（p>0.05）。在运动期间，SmO 的变化较低（p=0.02， =0.62），空气质量较差。这些初步发现表明，环境 WFS 暴露对健康成年人在运动期间肌肉微血管功能有适度影响。需要进一步研究以阐明 WFS 暴露的生理变化以及心血管事件风险增加的情况，这些风险可能因体力活动而加剧。
