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Can self-amplifying RNA vaccines and viruses exchange genetic material?

作者信息

Casmil Irafasha C, Blakney Anna K

机构信息

Michael Smith Laboratories, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.

Michael Smith Laboratories, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.

出版信息

Mol Ther. 2024 Aug 7;32(8):2437-2438. doi: 10.1016/j.ymthe.2024.07.003. Epub 2024 Jul 20.

DOI:10.1016/j.ymthe.2024.07.003
PMID:39032486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11405170/
Abstract
摘要

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2
Persistence of immune responses of a self-amplifying RNA COVID-19 vaccine (ARCT-154) versus BNT162b2.一种自我扩增RNA新冠疫苗（ARCT-154）与BNT162b2疫苗免疫反应的持久性
Lancet Infect Dis. 2024 Apr;24(4):341-343. doi: 10.1016/S1473-3099(24)00060-4. Epub 2024 Feb 1.
3
A localizing nanocarrier formulation enables multi-target immune responses to multivalent replicating RNA with limited systemic inflammation.一种定位纳米载体配方可使多价复制 RNA 引发多靶免疫反应，并将全身性炎症控制在有限范围内。
Mol Ther. 2023 Aug 2;31(8):2360-2375. doi: 10.1016/j.ymthe.2023.06.017. Epub 2023 Jul 3.
4
A new generation of vaccines based on alphavirus self-amplifying RNA.基于甲病毒自我扩增 RNA 的新一代疫苗。
Curr Opin Virol. 2020 Oct;44:145-153. doi: 10.1016/j.coviro.2020.08.003. Epub 2020 Sep 6.
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A Low Fidelity Virus Shows Increased Recombination during the Removal of an Alphavirus Reporter Gene.一种低保真病毒在去除甲病毒报告基因的过程中显示出更高的重组率。
Viruses. 2020 Jun 19;12(6):660. doi: 10.3390/v12060660.
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Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice.自扩增 RNA 疫苗可诱导小鼠产生抗委内瑞拉马脑炎病毒的强大保护免疫原性。
Mol Ther. 2019 Apr 10;27(4):850-865. doi: 10.1016/j.ymthe.2018.12.013. Epub 2019 Jan 7.
7
Unique safety issues associated with virus-vectored vaccines: Potential for and theoretical consequences of recombination with wild type virus strains.与病毒载体疫苗相关的独特安全问题：与野生型病毒株重组的可能性及理论后果。
Vaccine. 2016 Dec 12;34(51):6610-6616. doi: 10.1016/j.vaccine.2016.04.060. Epub 2016 Jun 23.
8
ClickSeq: Fragmentation-Free Next-Generation Sequencing via Click Ligation of Adaptors to Stochastically Terminated 3'-Azido cDNAs.ClickSeq：通过将接头连接到随机终止的3'-叠氮基cDNA上进行无片段化的下一代测序。
J Mol Biol. 2015 Aug 14;427(16):2610-6. doi: 10.1016/j.jmb.2015.06.011. Epub 2015 Jun 24.
9
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Homologous interference induced by Sindbis virus.辛德毕斯病毒诱导的同源干扰
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