Nuclear Medicine Department, ASST Spedali Civili of Brescia, 25123 Brescia, Italy.
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Nuclear Medicine, University of Brescia, 25123 Brescia, Italy.
Medicina (Kaunas). 2022 Jul 10;58(7):916. doi: 10.3390/medicina58070916.
: Ga-DOTA peptides positron emission tomography/computed tomography (PET/CT) is usually applied for the study of neuroendocrine tumours, but other tumours such as meningioma may also have an increased radiopharmaceutical uptake. The aim of this retrospective study was to establish the prevalence and the meaning of brain incidental uptake among patients who performed Ga-DOTA peptides PET/CT for other reasons. : Overall, 510 Ga-DOTA peptides PET/CT scans performed between January 2018 and February 2022 from 430 patients were reviewed for the analysis of incidental brain radiopharmaceutical uptake. All brain incidentalomas were compared with brain magnetic resonance imaging (MRI) and/or contrast-enhanced CT performed within an average time interval of ±60 days from PET/CT scan. : A total of 48 patients (14%) presented incidental focal intracranial radiotracer uptake. Thirty-eight (11%) of them had a suspected meningioma confirmed by MRI or contrast-enhanced CT imaging features. The remaining 10 had a final diagnosis different from meningioma (5 as brain metastases and 2 as venous anomalies) or were lost during the follow-up without performing MRI ( = 3). The average maximal standardized uptake value (SUVmax) of the suspected meningioma was 16.5 (range 5-33), and the average lesion to brain SUVmax ratio was 351 (range 80-550). : Brain incidental uptake from the Ga-DOTA peptides PET/CT is not so rare, and meningioma is the most frequent cause.
Ga-DOTA 肽正电子发射断层扫描/计算机断层扫描（PET/CT）通常用于神经内分泌肿瘤的研究，但脑膜瘤等其他肿瘤也可能有放射性药物摄取增加。本回顾性研究的目的是确定在因其他原因进行 Ga-DOTA 肽 PET/CT 的患者中，脑偶然摄取的发生率和意义。
在 2018 年 1 月至 2022 年 2 月期间，对 430 例患者的 510 例 Ga-DOTA 肽 PET/CT 扫描进行了回顾性分析，以评估脑放射性药物偶然摄取情况。所有偶然发现的脑肿瘤均与 PET/CT 扫描后平均时间间隔为±60 天内进行的脑磁共振成像（MRI）和/或增强 CT 进行了比较。
共有 48 例患者（14%）出现偶然的局灶性颅内放射性示踪剂摄取。其中 38 例（11%）被 MRI 或增强 CT 成像特征证实为疑似脑膜瘤。其余 10 例的最终诊断与脑膜瘤不同（5 例为脑转移瘤，2 例为静脉异常），或在未进行 MRI 随访期间丢失（=3）。疑似脑膜瘤的平均最大标准化摄取值（SUVmax）为 16.5（范围 5-33），病变与脑 SUVmax 比值的平均为 351（范围 80-550）。
Ga-DOTA 肽 PET/CT 的脑偶然摄取并不罕见，脑膜瘤是最常见的原因。
