Domman Daryl, Davis Sarah Shrum, Salazar-Hamm Paris, Edge Karen, Hanosh Tim, Houston Jessica, Griego-Fisher Anastacia, Lugo Francelli, Wenzel Nicholas, Malone D'Eldra, Bradford Carol, Plymesser Kelly, Baker Michael, Schwalm Kurt, Lathrop Sarah, Smelser Chad, Dinwiddie Darrell
University of New Mexico Health Sciences Center.
University of New Mexico Emerging Infections Program.
Res Sq. 2024 Jul 12:rs.3.rs-4682172. doi: 10.21203/rs.3.rs-4682172/v1.
Shigellosis is a gastrointestinal infection caused by species of . A large outbreak of serotype 2a occurred in Albuquerque, New Mexico (NM) between May 2021 and November 2023 that involved humans and nonhuman primates (NHP) from a local zoo. We analyzed the genomes of 202 New Mexico isolates as well as 15 closely related isolates from other states, and four from NHP. The outbreak was initially detected within men who have sex with men (MSM) but then predominantly affected people experiencing homelessness (PEH). Nearly 70% of cases were hospitalized and there was one human death. The outbreak extended into Albuquerque's BioPark Zoo, causing high morbidity and six deaths in NHPs. The NHP isolates were identical to those in the human outbreak. All isolates were multidrug-resistant, including towards fluoroquinolones, a first line treatment option which led to treatment failures in human and NHP populations. We demonstrate the transmission of this S. strain between humans and NHPs, causing fatalities in both populations. This study demonstrates the threat of antimicrobial resistant organisms to vulnerable human and primate populations and emphasizes the value of vigilant genomic surveillance within a One Health framework.
志贺氏菌病是一种由志贺氏菌属物种引起的胃肠道感染。2021年5月至2023年11月期间，新墨西哥州阿尔伯克基市发生了一起大规模的2a血清型志贺氏菌疫情，涉及当地动物园的人类和非人类灵长类动物（NHP）。我们分析了202株来自新墨西哥州的分离株以及15株来自其他州的密切相关分离株，还有4株来自非人类灵长类动物的分离株。疫情最初在男男性行为者（MSM）中被发现，但随后主要影响了无家可归者（PEH）。近70%的病例住院治疗，并有1人死亡。疫情蔓延至阿尔伯克基生物公园动物园，导致非人类灵长类动物高发病率和6例死亡。非人类灵长类动物的分离株与人类疫情中的分离株相同。所有分离株均具有多重耐药性，包括对氟喹诺酮类药物耐药，而氟喹诺酮类药物是一线治疗选择，这导致了人类和非人类灵长类动物群体的治疗失败。我们证明了这种志贺氏菌菌株在人类和非人类灵长类动物之间的传播，导致了两个群体的死亡。这项研究证明了抗菌耐药生物对脆弱的人类和灵长类动物群体的威胁，并强调了在“同一健康”框架内进行警惕的基因组监测的价值。
