Laboratory of Small Animal Surgery, Azabu University, Sagamihara, Kanagawa, Japan.
Vet Med Sci. 2024 Sep;10(5):e1549. doi: 10.1002/vms3.1549.
Cough is a common clinical complaint in small animal practice with limited treatment options for chronic underlying conditions.
The present study aimed to evaluate the efficacy of three antitussive drugs in a novel, minimally invasive canine acute cough model.
Five clinically healthy Beagles were used to create an acute cough model by administering sterile saline via a transtracheally placed central venous catheter. Single-dose antitussive effects of butorphanol, maropitant and Danpron were assessed. Cough frequency was measured before and at hourly intervals up to 3 h post-administration of each drug, with a linear mixed model used for statistical analysis.
Butorphanol (0.3 m/kg, IM) significantly reduced cough frequency at 1 and 3 h post-administration. Danpron (0.1 mL/kg, IM) also significantly reduced cough frequency 1 h post-administration; however, this effect was not sustained at 3 h. Maropitant (1 mg/kg, IM) did not significantly reduce cough frequency. The cough induction method was effective and minimally invasive, with no adverse effects.
The present study demonstrated that butorphanol has a potent and prolonged antitussive effect in an acute canine cough model, whereas Danpron shows a transient effect. These findings provide valuable insights into the comparative efficacy of commonly used antitussive drugs in dogs.
咳嗽是小动物临床实践中常见的主诉，对于慢性潜在疾病的治疗选择有限。
本研究旨在评估三种镇咳药物在新型微创犬急性咳嗽模型中的疗效。
使用 5 只临床健康的比格犬，通过经气管放置的中心静脉导管给予无菌生理盐水来建立急性咳嗽模型。评估了布托啡诺、马罗匹坦和丹普龙的单剂量镇咳效果。在给予每种药物前和给药后 1 小时内每小时测量咳嗽频率，使用线性混合模型进行统计分析。
布托啡诺（0.3 m/kg，IM）在给药后 1 小时和 3 小时显著降低了咳嗽频率。丹普龙（0.1 mL/kg，IM）在给药后 1 小时也显著降低了咳嗽频率；然而，这种效果在 3 小时时并未持续。马罗匹坦（1 mg/kg，IM）并未显著降低咳嗽频率。咳嗽诱导方法有效且微创，无不良反应。
本研究表明，布托啡诺在犬急性咳嗽模型中具有强大而持久的镇咳作用，而丹普龙则显示出短暂的效果。这些发现为常用镇咳药物在犬中的比较疗效提供了有价值的见解。
