Pang Bo, Guo Tongjun, Chen Xi, Guo Huaqi, Shi Jiazhang, Chen Juan, Wang Xinmei, Li Yaoyan, Shan Anqi, Yu Hengyi, Huang Jing, Tang Naijun, Wang Yan, Guo Xinbiao, Li Guoxing, Wu Shaowei
Department of Occupational and Environmental Health, Peking University School of Public Health, Beijing 100191, China.
Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2024 Aug 18;56(4):700-707. doi: 10.19723/j.issn.1671-167X.2024.04.025.
To investigate personal exposures to nitrogen oxides (NO) and nitrogen di-oxide (NO) and the influence of baseline personal characteristics, living environment and daily activity patterns of the participants on the exposures among adults over 35 in Tianjin and Shanghai.
In this panel study, 91 healthy nonsmoking adults aged over 35 from Tianjin and Shanghai participated in our study. The study was conducted in summer and winter. The participants were followed for three times with an interval of at least two weeks. Only participants in Shanghai were followed once in winter because of the COVID-19 pandemic. Twenty-seven participants completed follow-up visits in both seasons. We measured their 24 h personal exposures to NO and NOand collected their baseline and time-activity information through questionnaire/diary. The linear mixed model was used to analyze the associations between potential influencing factors and personal NO and NO exposure levels.
There were 349 follow-up visits with valid 24 h personal NO and NO exposure measurements in the two cities. The ave-rage 24 h personal exposures to NO and NO (volume fraction) in Tianjin participants were 18.0×10 and 26.2×10 in summer, and 31.0×10 and 54.9×10 in winter, respectively; and the average 24 h personal exposures to NO and NO in Shanghai participants were 38.7×10 and 100.0×10 in summer, and 45.5×10 and 139.2×10 in winter, respectively. The results of univariate regression analysis showed that their personal NO exposure levels were significantly associated with city, season, gender, average daily cooking times, and ambient NO concentrations measured at fixed-site monitoring stations. In addition to the above factors, the personal NO exposure levels were also significantly associated with educational level and the personal NO exposure levels were also significantly associated with passive smoking, average daily home time, cooking energy type, residential distance from main traffic road, and use of kitchen ventilators. Multivariate regression analysis showed that the personal exposure levels of NO and NO were significantly lower in Tianjin than that in Shanghai, were significantly lower in summer than that in winter, and were significantly and positively associated with ambient NO concentrations measured at fixed-site monitoring stations. In addition, personal NO exposure levels were significantly lower in females than in males, and personal NO exposure levels were significantly positively associated with average daily cooking times and significantly inversely associated with average daily home time. For every interquartile range () increase (12.7×10) in ambient NO, the personal NO exposure levels increased by 27.5% (95%: 17.0%-38.9%), and personal NO exposure levels increased by 16.1% (95%: 7.1%-25.8%).
Season, city and ambient NO concentrations are significant influencing factors of personal exposure levels of NOand NO At the same time, the personal exposures levels of NOare also affected by lifestyle factors. Our study provides scientific evidence for making precise air pollution control decisions and reducing the exposure levels of NO in the population.
调查天津市和上海市35岁以上成年人个人接触氮氧化物(NO)和二氧化氮(NO₂)的情况,以及参与者的基线个人特征、生活环境和日常活动模式对接触情况的影响。
在这项队列研究中,91名来自天津和上海的35岁以上健康非吸烟成年人参与了我们的研究。研究在夏季和冬季进行。参与者至少每两周随访一次,共随访三次。由于新冠疫情,上海的参与者仅在冬季随访一次。27名参与者在两个季节均完成了随访。我们测量了他们24小时个人接触NO和NO₂的情况,并通过问卷/日记收集了他们的基线和时间活动信息。采用线性混合模型分析潜在影响因素与个人NO和NO₂接触水平之间的关联。
两个城市共有349次随访,获得了有效的24小时个人NO和NO₂接触测量值。天津参与者夏季24小时个人平均接触NO和NO₂(体积分数)分别为18.0×10⁻⁹和26.2×10⁻⁹,冬季分别为31.0×10⁻⁹和54.9×10⁻⁹;上海参与者夏季24小时个人平均接触NO和NO₂分别为38.7×10⁻⁹和100.0×10⁻⁹,冬季分别为45.5×10⁻⁹和139.2×10⁻⁹。单因素回归分析结果显示,他们的个人NO接触水平与城市、季节、性别、平均每日烹饪次数以及固定站点监测站测量的环境NO浓度显著相关。除上述因素外,个人NO接触水平还与教育程度显著相关,个人NO₂接触水平还与被动吸烟、平均每日在家时间、烹饪能源类型、住宅与主要交通道路的距离以及厨房通风设备的使用显著相关。多因素回归分析显示,天津的个人NO和NO₂接触水平显著低于上海,夏季显著低于冬季,且与固定站点监测站测量的环境NO浓度显著正相关。此外,女性的个人NO接触水平显著低于男性,个人NO接触水平与平均每日烹饪次数显著正相关,与平均每日在家时间显著负相关。环境NO每增加一个四分位数间距(IQR)(12.7×10⁻⁹),个人NO接触水平增加27.5%(95%置信区间:17.0%-38.9%),个人NO₂接触水平增加16.1%(95%置信区间:7.1%-25.8%)。
季节、城市和环境NO浓度是个人NO和NO₂接触水平的重要影响因素。同时,个人NO接触水平也受到生活方式因素的影响。我们的研究为做出精确的空气污染控制决策和降低人群中NO的接触水平提供了科学依据。