State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Division of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona, Tucson, AZ, 85721-0202, USA.
Environ Sci Pollut Res Int. 2018 May;25(15):15133-15145. doi: 10.1007/s11356-018-1629-7. Epub 2018 Mar 20.
Exposure to nitrogen dioxide (NO) has long been linked to elevated mortality and morbidity from epidemiological evidences. However, questions remain unclear whether NO acts directly on human health or being an indicator of other ambient pollutants. In this study, random-effect meta-analyses were performed on examining exposure to nitrogen oxide (NO) and its association with chronic obstructive pulmonary disease (COPD). The overall relative risk (RR) of COPD risk related to a 10 μg/m increase in NO exposure increased by 2.0%. The pooled effect on prevalence was 17% with an increase of 10 μg/m in NO concentration, and 1.3% on hospital admissions, and 2.6% on mortality. The RR of COPD cases related to NO long-term exposure was 2.5 and 1.4% in short-term exposure. The COPD effect related with a 10 μg/m increase in exposure to a general outdoor-sourced NO was 1.7 and 17.8% to exposure to an exclusively traffic-sourced NO; importantly, we did observe the effect of NO on COPD mortality with a large majority in lag0. Long-term traffic exerted more severe impairments on COPD prevalence than long-term or short-term outdoor effect; long-term mortality effect on COPD was serious in single model from this meta-analysis. Overall, our study reported consistent evidence of the potential positive association between NO and COPD risk.
二氧化氮（NO）暴露长期以来一直与流行病学证据表明的死亡率和发病率升高有关。然而，人们仍不清楚 NO 是否直接作用于人类健康，还是其他环境污染物的指标。在这项研究中，我们对接触氮氧化物（NO）及其与慢性阻塞性肺疾病（COPD）的关系进行了随机效应荟萃分析。NO 暴露每增加 10μg/m3，COPD 风险的总体相对风险（RR）增加 2.0%。NO 浓度增加 10μg/m3 时，患病率的 pooled 效应增加 17%，住院人数增加 1.3%，死亡率增加 2.6%。与 NO 长期暴露相关的 COPD 病例 RR 为 2.5%和 1.4%，短期暴露 RR 为 2.5%和 1.4%。与暴露于一般室外源 NO 增加 10μg/m3 相关的 COPD 效应为 1.7%，与暴露于专门的交通源 NO 增加 17.8%；重要的是，我们确实观察到了 NO 对 COPD 死亡率的影响，且大多数在滞后 0 期。长期交通对 COPD 患病率的影响比长期或短期室外影响更为严重；从这项荟萃分析的单一模型来看，长期对 COPD 死亡率的影响是严重的。总体而言，我们的研究报告了一致的证据，表明 NO 与 COPD 风险之间存在潜在的正相关关系。
