Department of Pharmacology and Toxicology, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
Pharmacology Department, Faculty of Veterinary Medicine, Assiut University, Egypt, 71526, Egypt.
Int Urol Nephrol. 2024 Dec;56(12):3687-3718. doi: 10.1007/s11255-024-04148-9. Epub 2024 Jul 23.
Urolithiasis, the formation of kidney stones, is a common and severe condition. Despite advances in understanding its pathophysiology, affordable treatment options are needed worldwide. Hence, the interest is in herbal medicines as alternative or supplementary therapy for urinary stone disease. This review explores the use of plant extracts and phytochemicals in preventing and treating urolithiasis.
Following PRISMA standards, we systematically reviewed the literature on PubMed/Medline, focusing on herbal items evaluated in in vivo models, in vitro studies, and clinical trials related to nephrolithiasis/urolithiasis. We searched English language publications from January 2021 to December 2023. Studies assessing plant extracts and phytochemicals' therapeutic potential in urolithiasis were included. Data extracted included study design, stone type, plant type, part of plant used, solvent type, main findings, and study references.
A total of 64 studies were included. Most studies used ethylene glycol to induce hyperoxaluria and nephrolithiasis in rat models. Various extraction methods were used to extract bioactive compounds from different plant parts. Several plants and phytochemicals, including Alhagi maurorum, Aerva lanata, Dolichos biflorus, Cucumis melo, and quercetin, demonstrated potential effectiveness in reducing stone formation, size, and number.
Natural substances offer an alternative or supplementary approach to current treatments, potentially reducing pain and improving the quality of life for urolithiasis patients. However, further research is needed to clarify their mechanisms of action and optimize their therapeutic use. The potential of plant-based therapies in treating urolithiasis is promising, and ongoing research is expected to lead to treatment advancements benefiting patients globally.
肾结石的形成是一种常见且严重的疾病。尽管人们对其病理生理学有了深入的了解，但全球仍需要负担得起的治疗选择。因此，人们对草药作为治疗尿路结石疾病的替代或补充疗法产生了兴趣。本综述探讨了植物提取物和植物化学物质在预防和治疗肾结石病中的应用。
根据 PRISMA 标准，我们系统地检索了 PubMed/Medline 上的文献，重点关注在体内模型、体外研究和与肾结石/尿路结石相关的临床试验中评估的草药项目。我们检索了 2021 年 1 月至 2023 年 12 月发表的英文文献。纳入评估植物提取物和植物化学物质在肾结石病治疗中的潜在作用的研究。提取的数据包括研究设计、结石类型、植物类型、植物使用部分、溶剂类型、主要发现和研究参考文献。
共纳入 64 项研究。大多数研究使用乙二醇诱导大鼠模型的高草酸尿症和肾结石形成。不同的提取方法用于从不同的植物部位提取生物活性化合物。包括骆驼刺、三白草、木豆、甜瓜和槲皮素在内的几种植物和植物化学物质在减少结石形成、大小和数量方面显示出潜在的有效性。
天然物质为当前治疗方法提供了一种替代或补充方法，可能减轻肾结石病患者的疼痛并提高其生活质量。然而，需要进一步研究以阐明其作用机制并优化其治疗用途。植物疗法治疗肾结石病的潜力是有希望的，预计正在进行的研究将为全球患者带来治疗进展。
