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与储存纳洛酮相关的因素:社区药剂师的横断面调查。

Correlates of stocking naloxone: a cross-sectional survey of community pharmacists.

机构信息

Monash Addiction Research Centre, Eastern Health Clinical School, Peninsula Campus, Monash University, 47-49 Moorooduc Hwy, VIC 3199, Frankston, Melbourne, Australia.

出版信息

Int J Clin Pharm. 2024 Dec;46(6):1362-1370. doi: 10.1007/s11096-024-01773-3. Epub 2024 Jul 23.

Abstract

BACKGROUND

Provision of take-home naloxone (THN) and overdose education reduces opioid-related mortality. In Australia, from July 2022, all Australian community pharmacies were eligible to supply naloxone for free through the national THN Program.

AIM

This study aimed to identify naloxone stocking rates and correlates of stocking naloxone across Australian pharmacies.

METHOD

Data were collected from a representative sample of Australian pharmacists in Victoria, New South Wales, Queensland and Western Australia via an online survey. Data collected included pharmacy and pharmacist characteristics and services offered within the pharmacy, including needle and syringe programs, opioid agonist treatment (OAT) and stocking naloxone. Binary probit regression analysis was used to identify correlates of stocking naloxone after controlling for key covariates.

RESULTS

Data from 530 pharmacists were analysed. In total, 321 pharmacies (60.6%) reported stocking naloxone. Chain pharmacies and pharmacies that provided OAT had a greater probability of stocking naloxone (B = 0.307, 95%CI: [0.057, 0.556], and B = 0.543, 95%CI: [0.308, 0.777] respectively). Most (61.7%) pharmacists felt comfortable discussing overdose prevention with patients who use prescription opioids, and this comfort was associated with a higher probability of stocking naloxone (B = 0.392, 95%CI: 0.128, 0.655). Comfort discussing overdose prevention with people who use illicit opioids was lower (49.4%) and was not associated with stocking naloxone.

CONCLUSION

There is scope to increase stocking of naloxone and comfort with overdose prevention, particularly through addressing comfort working with higher risk groups such as people who use illicit opioids.

摘要

背景

提供纳洛酮带回家(THN)和过量用药教育可降低阿片类药物相关死亡率。自 2022 年 7 月起,澳大利亚所有社区药房都有资格通过国家 THN 计划免费供应纳洛酮。

目的

本研究旨在确定澳大利亚各地药房纳洛酮的库存率及其与纳洛酮库存的相关性。

方法

通过对维多利亚州、新南威尔士州、昆士兰州和西澳大利亚州的代表性澳大利亚药剂师进行在线调查,收集数据。收集的数据包括药房和药剂师的特征以及药房内提供的服务,包括针具和注射器计划、阿片类药物激动剂治疗(OAT)和纳洛酮库存。在控制关键协变量后,使用二元概率回归分析来确定纳洛酮库存的相关性。

结果

分析了 530 名药剂师的数据。共有 321 家(60.6%)药房报告库存纳洛酮。连锁药房和提供 OAT 的药房更有可能库存纳洛酮(B=0.307,95%CI:[0.057,0.556]和 B=0.543,95%CI:[0.308,0.777])。大多数(61.7%)药剂师在与使用处方阿片类药物的患者讨论预防过量用药时感到舒适,这种舒适度与更高的纳洛酮库存概率相关(B=0.392,95%CI:0.128,0.655)。与使用非法阿片类药物的人讨论预防过量用药的舒适度较低(49.4%),与库存纳洛酮无关。

结论

增加纳洛酮的库存和预防过量用药的舒适度仍有空间,特别是通过解决与高风险群体(如使用非法阿片类药物的人)合作的舒适度问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e390/11576638/c1d2a0f83766/11096_2024_1773_Fig1_HTML.jpg

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