Singh Nihal, Sharma Anoop, Singh Jitender, Pandey Amar Prakash, Sharma Anuj
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India.
Org Lett. 2024 Aug 2;26(30):6471-6476. doi: 10.1021/acs.orglett.4c02296. Epub 2024 Jul 23.
Visible light-induced C-3 arylation of quinoxalin-2(1)-ones with abundantly available aryl iodides with good yields via an electron-donor-acceptor (EDA)-complex formation have been accomplished. The radical scavenging, Electron paramagnetic resonance (EPR), UV-visible experiments, density functional theory (DFT), and quantum yield studies revealed that the reaction went through a radical pathway via a single electron transfer (SET) process. Furthermore, the protocol could also be applied to the synthesis of biologically active molecules, illustrating the practicality of the present protocol.
通过形成电子给体-受体（EDA）络合物，实现了可见光诱导喹喔啉-2(1)-酮与大量可得的芳基碘发生C-3芳基化反应，产率良好。自由基清除、电子顺磁共振（EPR）、紫外-可见光谱实验、密度泛函理论（DFT）和量子产率研究表明，该反应通过单电子转移（SET）过程经由自由基途径进行。此外，该方法还可应用于生物活性分子的合成，证明了本方法的实用性。
