Zheng Haoxiao, Zhu Hailan, Liu Xinyue, Huang Xiaohui, Huang Anqing, Huang Yuli
Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.
Guangdong Provincial Key Laboratory of Shock and Microcirculation Research, Guangzhou, China.
Front Cell Dev Biol. 2021 Sep 27;9:750382. doi: 10.3389/fcell.2021.750382. eCollection 2021.
Cardiovascular disease is the leading complication of diabetes mellitus (DM), and diabetic cardiomyopathy (DCM) is a major cause of mortality in diabetic patients. Multiple pathophysiologic mechanisms, including myocardial insulin resistance, oxidative stress and inflammation, are involved in the development of DCM. Recent studies have shown that mitochondrial dysfunction makes a substantial contribution to the development of DCM. Mitophagy is a type of autophagy that takes place in dysfunctional mitochondria, and it plays a key role in mitochondrial quality control. Although the precise molecular mechanisms of mitophagy in DCM have yet to be fully clarified, recent findings imply that mitophagy improves cardiac function in the diabetic heart. However, excessive mitophagy may exacerbate myocardial damage in patients with DCM. In this review, we aim to provide a comprehensive overview of mitochondrial quality control and the dual roles of mitophagy in DCM. We also propose that a balance between mitochondrial biogenesis and mitophagy is essential for the maintenance of cellular metabolism in the diabetic heart.
心血管疾病是糖尿病（DM）的主要并发症，而糖尿病性心肌病（DCM）是糖尿病患者死亡的主要原因。多种病理生理机制，包括心肌胰岛素抵抗、氧化应激和炎症，都参与了DCM的发生发展。最近的研究表明，线粒体功能障碍在DCM的发生发展中起重要作用。线粒体自噬是一种发生在功能失调线粒体中的自噬类型，它在线粒体质量控制中起关键作用。虽然DCM中线粒体自噬的确切分子机制尚未完全阐明，但最近的研究结果表明，线粒体自噬可改善糖尿病心脏的心脏功能。然而，过度的线粒体自噬可能会加重DCM患者的心肌损伤。在这篇综述中，我们旨在全面概述线粒体质量控制以及线粒体自噬在DCM中的双重作用。我们还提出，线粒体生物合成和线粒体自噬之间的平衡对于维持糖尿病心脏的细胞代谢至关重要。
