São Paulo State University (UNESP), Medical School, Distrito de Rubião Junior s/n - Botucatu (SP), Brazil.
Rev Assoc Med Bras (1992). 2024 Jul 19;70(7):e20231379. doi: 10.1590/1806-9282.20231379. eCollection 2024.
The aim of this study was to evaluate the efficacy of long-term oxygen therapy as a strategy to reduce hospitalization time in patients affected by COVID-19.
Between April and December 2021, COVID-19 patients with stable clinical conditions needing supplementary oxygen therapy during hospitalization were oriented to have hospital discharge with long-term oxygen therapy and reassessment after 15 days.
A total of 62 patients were evaluated and, 15 days after discharge, 69% of patients had suspended long-term oxygen therapy, with no difference between the groups admitted to the intensive care unit or the ward (p=0.319). Among the individuals who needed to maintain long-term oxygen therapy, in addition to worse P/F ratio (265±57 vs. 345±51; p<0.001) and lower partial pressure of oxygen (55±12 vs. 72±11 mmHg; p<0.001), were those more obese (37±8 vs. 30±6 kg/m2; p=0.032), needed more time for invasive mechanical ventilation (46±27 vs. 20±16 days; p=0.029), had greater persistence of symptoms (p<0.001), and shorter time between the onset of symptoms and the need for hospitalization (7 [2-9] vs. 10 [6-12] days; p=0.039).
Long-term oxygen therapy is an effective strategy for reducing hospitalization time in COVID-19 patients, regardless of gravity. Additionally, more obese patients with persistence of respiratory symptoms, faster disease evolution, and more days of invasive mechanical ventilation needed to maintain the long-term oxygen therapy longer.
本研究旨在评估长期氧疗作为降低 COVID-19 患者住院时间的策略的疗效。
在 2021 年 4 月至 12 月期间，将需要在住院期间接受补充氧疗的稳定临床状态的 COVID-19 患者定向出院，并在 15 天后进行重新评估。
共评估了 62 例患者，出院后 15 天，69%的患者停止了长期氧疗，入住重症监护病房和病房的患者之间无差异（p=0.319）。在需要维持长期氧疗的患者中，除了 P/F 比值（265±57 比 345±51；p<0.001）和氧分压（55±12 比 72±11mmHg；p<0.001）更低外，他们还更肥胖（37±8 比 30±6kg/m2；p=0.032），需要更长时间的有创机械通气（46±27 比 20±16 天；p=0.029），症状持续时间更长（p<0.001），从症状发作到住院的时间更短（7[2-9]比 10[6-12]天；p=0.039）。
长期氧疗是降低 COVID-19 患者住院时间的有效策略，与严重程度无关。此外，肥胖患者、呼吸症状持续时间更长、疾病进展更快以及需要更多天数的有创机械通气来维持长期氧疗的患者，需要更长时间的氧疗。
