Hull University Teaching Hospitals Trust, Respiratory Clinical Trials Unit, Daisy Building, Castle Hill Hospital, Hull, HU16 5JQ, UK.
Hull York Medical School, Hull, UK.
Lung. 2021 Apr;199(2):113-119. doi: 10.1007/s00408-021-00423-z. Epub 2021 Feb 11.
The enduring impact of COVID-19 on patients has been examined in recent studies, leading to the description of Long-COVID. We report the lasting symptom burden of COVID-19 patients from the first wave of the pandemic. All patients with COVID-19 pneumonia discharged from a large teaching hospital trust were offered follow-up. We assessed symptom burden at follow-up using a standardised data collection technique during virtual outpatient clinic appointments. Eighty-six percent of patients reported at least one residual symptom at follow-up. No patients had persistent radiographic abnormalities. The presence of symptoms at follow-up was not associated with the severity of the acute COVID-19 illness. Females were significantly more likely to report residual symptoms including anxiety (p = 0.001), fatigue (p = 0.004), and myalgia (p = 0.022). The presence of long-lasting symptoms is common in COVID-19 patients. We suggest that the phenomenon of Long-COVID may not be directly attributable to the effect of SARS-CoV-2, and believe the biopsychosocial effects of COVID-19 may play a greater role in its aetiology.
近期研究调查了 COVID-19 对患者的持久影响，由此产生了“长新冠”的概念。我们报告了大流行第一波期间 COVID-19 患者的持续症状负担。从一家大型教学医院信托中出院的所有 COVID-19 肺炎患者都被提供了随访。我们在虚拟门诊预约期间使用标准化的数据收集技术评估随访时的症状负担。86%的患者报告在随访时至少存在一种残留症状。没有患者存在持续的放射影像学异常。随访时存在症状与急性 COVID-19 疾病的严重程度无关。女性更有可能报告残留症状，包括焦虑（p=0.001）、疲劳（p=0.004）和肌痛（p=0.022）。COVID-19 患者中存在持久症状是很常见的。我们认为“长新冠”现象可能并非直接归因于 SARS-CoV-2 的影响，并且相信 COVID-19 的生物心理社会影响可能在其发病机制中发挥更大作用。
