School of Health Science & Engineering, University of Shanghai for Science & Technology, Shanghai, 200093, China.
Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai, 200433, China.
Nanomedicine (Lond). 2024;19(14):1297-1311. doi: 10.1080/17435889.2024.2347197. Epub 2024 May 30.
To develop a robust drug-delivery system using multi-arm amphiphilic block copolymers for enhanced efficacy in cancer therapy. Two series of amphiphilic polymer micelles, PEG-b-PCL and PEG-b-PCL/TPGS, were synthesized. Doxorubicin (DOX) loading into the micelles was achieved via solvent dialysis. The micelles displayed excellent biocompatibility, narrow size distribution, and uniform morphology. DOX-loaded micelles exhibited enhanced antitumor efficacy and increased drug accumulation at tumor sites compared with free DOX. Additionally, 4A-PEG-b-PCL/TPGS micelles effectively suppressed drug-resistant MCF-7/ADR cells. This study introduces a novel micelle formulation with exceptional serum stability and efficacy against drug resistance, promising for cancer therapy. It highlights innovative strategies for refining clinical translation and ensuring sustained efficacy and safety .
利用多臂两亲嵌段共聚物开发一种稳健的药物输送系统，以提高癌症治疗的疗效。 合成了两种两亲聚合物胶束，PEG-b-PCL 和 PEG-b-PCL/TPGS。 通过溶剂透析将阿霉素（DOX）载入胶束中。 胶束表现出良好的生物相容性、窄的粒径分布和均匀的形态。与游离 DOX 相比，载 DOX 的胶束显示出增强的抗肿瘤功效和增加的肿瘤部位药物积累。此外，4A-PEG-b-PCL/TPGS 胶束有效地抑制了耐药 MCF-7/ADR 细胞。 本研究介绍了一种具有出色血清稳定性和抗耐药性的新型胶束制剂，有望用于癌症治疗。它突出了用于确保持续疗效和安全性的创新策略的重要性。
