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用于乳腺癌治疗药物递送系统的脂质基纳米材料

Lipid-Based Nanomaterials for Drug Delivery Systems in Breast Cancer Therapy.

作者信息

Rethi Lekshmi, Mutalik Chinmaya, Anurogo Dito, Lu Long-Sheng, Chu Hsiu-Yi, Yougbaré Sibidou, Kuo Tsung-Rong, Cheng Tsai-Mu, Chen Fu-Lun

机构信息

International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.

International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.

出版信息

Nanomaterials (Basel). 2022 Aug 26;12(17):2948. doi: 10.3390/nano12172948.

Abstract

Globally, breast cancer is one of the most prevalent diseases, inducing critical intimidation to human health. Lipid-based nanomaterials have been successfully demonstrated as drug carriers for breast cancer treatment. To date, the development of a better drug delivery system based on lipid nanomaterials is still urgent to make the treatment and diagnosis easily accessible to breast cancer patients. In a drug delivery system, lipid nanomaterials have revealed distinctive features, including high biocompatibility and efficient drug delivery. Specifically, a targeted drug delivery system based on lipid nanomaterials has inherited the advantage of optimum dosage and low side effects. In this review, insights on currently used potential lipid-based nanomaterials are collected and introduced. The review sheds light on conjugation, targeting, diagnosis, treatment, and clinical significance of lipid-based nanomaterials to treat breast cancer. Furthermore, a brighter side of lipid-based nanomaterials as future potential drug delivery systems for breast cancer therapy is discussed.

摘要

在全球范围内,乳腺癌是最普遍的疾病之一,对人类健康构成严重威胁。基于脂质的纳米材料已成功证明可作为治疗乳腺癌的药物载体。迄今为止,基于脂质纳米材料开发更好的药物递送系统对于使乳腺癌患者易于接受治疗和诊断仍然十分迫切。在药物递送系统中,脂质纳米材料展现出独特的特性,包括高生物相容性和高效的药物递送。具体而言,基于脂质纳米材料的靶向药物递送系统继承了最佳剂量和低副作用的优势。在本综述中,收集并介绍了目前使用的潜在脂质基纳米材料的相关见解。该综述阐述了脂质基纳米材料在治疗乳腺癌方面的共轭、靶向、诊断、治疗及临床意义。此外,还讨论了脂质基纳米材料作为未来乳腺癌治疗潜在药物递送系统的光明前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add0/9458017/3fea9bb7d785/nanomaterials-12-02948-g001.jpg

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