Gholami Chahkand Mohammad Sadra, Esmaeilpour Moallem Fatemeh, Ghasemi-Kebria Fatemeh, Malekzadeh Reza, Roshandel Gholamreza, Taher Mohammad
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Middle East J Dig Dis. 2024 Jan;16(1):28-33. doi: 10.34172/mejdd.2024.365. Epub 2024 Jan 31.
We aim to present incidence rates and geographical distribution of most common early-onset gastrointestinal cancers (EOGICs), including early-onset esophageal cancer (EOEC), gastric cancer (EOGC) and colorectal cancer (EOCRC) in Iran, 2014-2018.
Data on new cases of EOEC, EOGC and EOCRC were obtained from publicly available annual reports of the Iranian National Population-based Cancer Registry (INPCR). Incidence rates were calculated using the population data available from the Statistical center of Iran. We considered the World standard population for calculation of age-standardized incidence rates (ASR). We also calculated 95% confidence intervals (CIs) for ASR. All rates are presented per 100000 person-years.
Overall, 19,679 new cases of EOGIC were registered by the INPCR between 2014 and 2018. The ASRs (95% CI) of EOEC, EOGC and EOCRC were 0.49 (95% CI: 0.47-0.51), 1.67 (1.63-1.71), and 3.07 (3.01-3.13) per 100,000 person-years, respectively. Our findings indicate decreasing and constant trends in the ASR of EOEC and EOGC during the study period, 2014-2018. There was an increasing trend in the ASR of EOCRC. We also found geographical disparities in the incidence rates of EOGICs across provinces of Iran, suggesting the highest ASRs of EOEC in Golestan (1.3), EOGC in Ilam (2.99) and EOCRC in Ilam (4.49).
Our findings suggested that the incidence rate of EOCRC is consistently increasing. We also found variations in the incidence of EOGICs among different provinces. Further investigations are recommended to clarify the time trends and risk factors of EOGICs in Iran.
我们旨在呈现2014 - 2018年伊朗最常见的早发性胃肠道癌症（EOGICs）的发病率及地理分布情况，包括早发性食管癌（EOEC）、胃癌（EOGC）和结直肠癌（EOCRC）。
EOEC、EOGC和EOCRC新发病例的数据来自伊朗国家人群癌症登记处（INPCR）公开的年度报告。发病率使用伊朗统计中心提供的人口数据进行计算。我们采用世界标准人口来计算年龄标准化发病率（ASR）。我们还计算了ASR的95%置信区间（CIs）。所有发病率均按每100000人年呈现。
总体而言，2014年至2018年间，INPCR登记了19679例EOGIC新发病例。EOEC、EOGC和EOCRC的ASR（95%CI）分别为每100000人年0.49（95%CI：0.47 - 0.51）、1.67（1.63 - 1.71）和3.07（3.01 - 3.13）。我们的研究结果表明，在2014 - 2018年研究期间，EOEC和EOGC的ASR呈下降和稳定趋势。EOCRC的ASR呈上升趋势。我们还发现伊朗各省份EOGICs发病率存在地理差异，提示戈尔斯坦省EOEC的ASR最高（1.3），伊拉姆省EOGC的ASR最高（2.99），伊拉姆省EOCRC的ASR最高（4.49）。
我们的研究结果表明EOCRC的发病率持续上升。我们还发现不同省份EOGICs的发病率存在差异。建议进一步开展调查以明确伊朗EOGICs的时间趋势和危险因素。
