Department of Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Nanjing, Jiangsu 210008, China.
Cereb Cortex. 2024 Jul 3;34(7). doi: 10.1093/cercor/bhae299.
Subjective cognitive decline (SCD) is considered an early indicator of Alzheimer's disease. Previous evidence suggests that postmenopausal females are at heightened risk for developing dementia. However, the potential effects of gender (i.e. postmenopausal female) on functional connectivity density (FCD) in individuals with SCD are not well understood. A total of 56 healthy controls and 57 subjects with SCD were included. The short-range and long-range FCD (srFCD and lrFCD) mapping of each participant was calculated. The interactive effect of gender × diagnosis on the FCD was explored by two-way analysis of variance. The interaction effect of gender × diagnosis on lrFCD was primarily in the right middle frontal gyrus (MFG). The older males with SCD exhibited significantly enhanced lrFCD in the right MFG relative to other subgroups. The lrFCD of the right MFG was positively associated with cognitive performance in older females with SCD. Cognition-related functional terms were significantly related to the right MFG. Decreased lrFCD of the right MFG in cognitively normal older women may explain why postmenopausal females have a higher risk for progression to dementia than men. Furthermore, this altered pattern could be applied to identify individuals with a high risk for dementia.
主观认知下降（SCD）被认为是阿尔茨海默病的早期指标。先前的证据表明，绝经后女性患痴呆症的风险增加。然而，性别（即绝经后女性）对 SCD 个体功能连接密度（FCD）的潜在影响尚不清楚。共纳入 56 名健康对照者和 57 名 SCD 患者。计算了每位参与者的短程和长程 FCD（srFCD 和 lrFCD）图谱。通过双向方差分析探讨了性别×诊断对 FCD 的交互作用。性别×诊断对 lrFCD 的交互作用主要在右侧额中回（MFG）。与其他亚组相比，患有 SCD 的老年男性右 MFG 的 lrFCD 明显增强。SCD 老年女性右 MFG 的 lrFCD 与认知表现呈正相关。与认知相关的功能术语与右侧 MFG 显著相关。认知正常的老年女性右侧 MFG 的 lrFCD 降低可能解释了为什么绝经后女性比男性更容易发展为痴呆症。此外，这种改变的模式可以用于识别痴呆症高危个体。
