Meister P, Gokel J M, Remberger K
Pathol Res Pract. 1979 Aug;164(4):402-12. doi: 10.1016/S0344-0338(79)80057-6.
A comparison of light, immunofluorescence and electron microscopic findings in palmar fibromatosis (Dupuytren's disease) revealed that the three morphologic phase of Luck; I. proliferative, 2. involutional, and 3. residual, corresponded for the most part to I. fibroblastic, 2. myofibroblastic or 3. fibrocytic lesions, respectively. The spectrum between proliferative phase and residual phase appeared immunohistochemically as a decrease in collagen type III, and an increase of collagen type I. Myosin was found in substantial quantities only during the involutional phase, distinguished by myofibroblasts, presumably with contractile capabilities. Thus, the clinical presence of contractures with palmar fibromatosis might also be explained in the absence of distinct fiber formation.
掌腱膜纤维瘤病（杜普伊特伦挛缩症）的光镜、免疫荧光及电镜检查结果比较显示，勒克的三个形态学阶段：1. 增殖期，2. 退化期，3. 残留期，在很大程度上分别对应于1. 成纤维细胞性、2. 肌成纤维细胞性或3. 纤维细胞性病变。增殖期和残留期之间的变化在免疫组织化学上表现为III型胶原减少，I型胶原增加。仅在退化期发现大量肌球蛋白，其特征为肌成纤维细胞，推测具有收缩能力。因此，在没有明显纤维形成的情况下，也可以解释掌腱膜纤维瘤病挛缩的临床表现。
