Jin Yuming, Huang Weichao, Zeng Bin, Yang Lu, Wang Shengfeng, Manuel Colucci, Daniele Robesti, Deng Linghui, Leng Siqi, Hu Dan, Wang Daming, Jiang Zhongyuan, Yi Qinling, Zhang Li, Zeng Yuxiao, Zhu Wenjie, Li Sheng, Liu Xinyue, Wei Qiang, Qiu Shi
Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University.
West China Biomedical Big Data Center, West China Hospital, Sichuan University.
Int J Surg. 2025 Jan 1;111(1):502-511. doi: 10.1097/JS9.0000000000001965.
Assessing urinary symptoms poses a complex challenge for primary care practitioners. In evaluating urological function, authors' approach involves constructing an urological age through the analysis of laboratory parameters and indicators of the urinary system.
Based on the National Health and Nutrition Examination Survey (NHANES), urological laboratory tests and age-related symptoms were included in the development of urological age (UA) and urological age acceleration (UAA) through the Klemera Doubal method. In relation to mortality associated with UAA, the metric was categorized into grades (0, 1, 2) as a discrete variable. The authors investigated the correlation between UAA and its grades with mortality, conducted survival analysis based on UAA grades, and explored the correlation between multi-system ageing-related disorders and UAA grades based on the NHANES and the West China Natural Population Cohort Study.
UA was related to age with the r to 0.85 in men and 0.84 in women. Each year the increase in UAA was related to higher 1% and 4% mortality for men and women. Those with UAA grades 1 and 2 were associated with more risk of mortality than individuals with UAA grade 0 (men 8% and 40%, women 24% and 157%). The advanced UAA grades kept pace with multi-system ageing. Healthy diets and lifestyle habits are associated with lower UAA.
Urological age is related to multi-system ageing and increases mortality risk, and urological age can be used to screen high-risk individuals and inform precision clinical development for ageing intervention.
对初级保健从业者而言，评估泌尿系统症状是一项复杂的挑战。在评估泌尿系统功能时，作者的方法是通过分析实验室参数和泌尿系统指标来构建一个泌尿系统年龄。
基于美国国家健康与营养检查调查（NHANES），通过克莱梅拉·杜巴尔方法，将泌尿系统实验室检查和与年龄相关的症状纳入泌尿系统年龄（UA）和泌尿系统年龄加速（UAA）的制定中。关于与UAA相关的死亡率，该指标被分类为等级（0、1、2）作为一个离散变量。作者研究了UAA及其等级与死亡率之间的相关性，基于UAA等级进行了生存分析，并基于NHANES和华西自然人群队列研究探讨了多系统衰老相关疾病与UAA等级之间的相关性。
UA与年龄相关，男性的相关系数为0.85，女性为0.84。每年UAA的增加与男性和女性死亡率分别升高1%和4%相关。UAA等级为1和2的人群比UAA等级为0的人群具有更高的死亡风险（男性为8%和40%，女性为24%和157%）。较高的UAA等级与多系统衰老同步。健康的饮食和生活习惯与较低的UAA相关。
泌尿系统年龄与多系统衰老相关并增加死亡风险，泌尿系统年龄可用于筛查高危个体并为衰老干预的精准临床发展提供依据。
