Division of Musculoskeletal & Dermatological Sciences, School of Biological Science.
Wellcome Centre for Cell-Matrix Research, School of Biological Science, Faculty of Biology, Medicine and Health, The University of Manchester.
Curr Opin Nephrol Hypertens. 2023 Nov 1;32(6):551-558. doi: 10.1097/MNH.0000000000000916. Epub 2023 Aug 16.
Matrikines are cell-signalling extracellular matrix fragments and they have attracted recent attention from basic and translational scientists, due to their diverse roles in age-related disease and their potential as therapeutic agents. In kidney, the matrix undergoes remodelling by proteolytic fragmentation, so matrikines are likely to play a substantial, yet understudied, role in ageing and pathogenesis of age-related diseases.
This review presents an up-to-date description of known matrikines with either a confirmed or highly anticipated role in kidney ageing and disease, including their point of origin, mechanism of cleavage, a summary of known biological actions and the current knowledge which links them to kidney health. We also highlight areas of interest, such as the prospect of matrikine cross-tissue communication, and gaps in knowledge, such as the unexplored signalling potential of many kidney disease-specific matrix fragments.
We anticipate that knowledge of specific matrikines, and their roles in controlling processes of kidney pathology, could be leveraged for the development of exciting new future therapies through inhibition or even with their supplementation.
基质细胞衍生因子是细胞信号传导的细胞外基质片段，由于它们在与年龄相关的疾病中的多种作用及其作为治疗剂的潜力，最近引起了基础和转化科学家的关注。在肾脏中，基质通过蛋白水解片段进行重塑，因此基质细胞衍生因子很可能在衰老和与年龄相关的疾病的发病机制中发挥重要但研究不足的作用。
本综述介绍了已知在肾脏衰老和疾病中具有明确或高度预期作用的基质细胞衍生因子，包括它们的起源、切割机制、已知生物学作用的总结以及将它们与肾脏健康联系起来的现有知识。我们还强调了一些感兴趣的领域，例如基质细胞衍生因子跨组织通讯的前景，以及许多肾脏疾病特异性基质片段的未探索信号转导潜力等知识空白。
我们预计，特定基质细胞衍生因子的知识及其在控制肾脏病理过程中的作用，可以通过抑制甚至补充这些因子，为开发令人兴奋的新未来疗法提供依据。
