Department of Microbiology and Molecular Genetics, and Department of Molecular and Cellular Biology, University of California, Davis, CA, 95616, USA.
Extremophiles. 2024 Jul 25;28(3):35. doi: 10.1007/s00792-024-01350-6.
3' → 5' exoribonucleases play a critical role in many aspects of RNA metabolism. RNase R, PNPase, and RNase II are the major contributors to RNA processing, maturation, and quality control in bacteria. Bacteria don't seem to have dedicated RNA degradation machineries to process different classes of RNAs. Under different environmental and physiological conditions, their roles can be redundant and sometimes overlapping. Here, I discuss why PNPase and RNase R may have switched their physiological roles in some bacterial species to adapt to environmental conditions, despite being biochemically distinct exoribonucleases.
3′→5′外切核糖核酸酶在 RNA 代谢的许多方面发挥着关键作用。RNase R、PNPase 和 RNase II 是细菌中 RNA 加工、成熟和质量控制的主要贡献者。细菌似乎没有专门的 RNA 降解机制来处理不同类别的 RNA。在不同的环境和生理条件下，它们的作用可能是冗余的，有时甚至是重叠的。在这里，我讨论了为什么 PNPase 和 RNase R 可能已经在某些细菌物种中改变了它们的生理作用，以适应环境条件，尽管它们在生化上是不同的外切核糖核酸酶。
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