2011-2014 年孟加拉国达卡地区婴幼儿口服轮状病毒疫苗接种状态对轮状病毒脱落和持续时间的影响差异。
Differences in Rotavirus Shedding and Duration by Infant Oral Rotavirus Vaccination Status in Dhaka, Bangladesh, 2011-2014.
机构信息
Department of Epidemiology, Emory University, Atlanta, Georgia, USA.
Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
出版信息
J Infect Dis. 2024 Jul 25;230(1):e75-e79. doi: 10.1093/infdis/jiad502.
To evaluate how breakthrough rotavirus disease contributes to transmission, we examined the impact of rotavirus vaccination on fecal shedding and duration of illness. We used multivariable linear regression to analyze rotavirus quantity by RT-qPCR and duration among 184 episodes of rotavirus diarrhea positive by ELISA in the PROVIDE study. Vaccinated children had less fecal viral shedding compared to unvaccinated children (mean difference = -0.59 log copies per gram of stool; 95% confidence interval [CI], -.99 to -.19). Duration of illness was on average 0.47 days (95% CI, -.23 to 1.17 days) shorter among vaccinated children. Rotarix vaccination reduces shedding burden among breakthrough cases of rotavirus gastroenteritis. Clinical Trials Registration . NCT01375647.
为了评估突破性轮状病毒病对传播的贡献，我们研究了轮状病毒疫苗接种对粪便排出和疾病持续时间的影响。我们使用多变量线性回归分析 PROVIDE 研究中通过 ELISA 检测为轮状病毒腹泻阳性的 184 例轮状病毒腹泻患者的 RT-qPCR 轮状病毒数量和持续时间。与未接种疫苗的儿童相比，接种疫苗的儿童粪便病毒排出量较少（平均差异=-0.59 对数拷贝/克粪便；95%置信区间（CI），-0.99 至-0.19）。接种疫苗的儿童的疾病持续时间平均缩短了 0.47 天（95%CI，-0.23 至 1.17 天）。罗特利克斯疫苗接种可降低突破性轮状病毒胃肠炎病例的脱落负担。临床试验注册。NCT01375647。
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