Burnett Eleanor, Jonesteller Christine L, Tate Jacqueline E, Yen Catherine, Parashar Umesh D
CDC Foundation.
Centers for Disease Control and Prevention, Atlanta, Georgia.
J Infect Dis. 2017 Jun 1;215(11):1666-1672. doi: 10.1093/infdis/jix186.
In 2006, 2 rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from countries with high child mortality. We used standardized guidelines (PRISMA) to identify observational evaluations of rotavirus vaccine impact among children <5 years of age that presented at least 12 months of pre- and post-vaccine introduction surveillance data. We identified 57 articles from 27 countries. Among children <5 years of age, the median percentage reduction in AGE hospitalizations was 38% overall and 41%, 30%, and 46% in countries with low, medium, and high child mortality, respectively. Hospitalizations and emergency department visits due to rotavirus AGE were reduced by a median of 67% overall and 71%, 59%, and 60% in countries with low, medium, and high child mortality, respectively. Implementation of rotavirus vaccines has substantially decreased hospitalizations from rotavirus and all-cause AGE.
2006年，两种轮状病毒疫苗获得许可。我们总结了自疫苗许可后的头10年里，轮状病毒疫苗对轮状病毒导致的住院和死亡以及全因急性胃肠炎（AGE）的影响，包括来自儿童死亡率高的国家的最新证据。我们使用标准化指南（PRISMA）来识别对5岁以下儿童轮状病毒疫苗影响的观察性评估，这些评估提供了至少12个月的疫苗引入前和引入后监测数据。我们从27个国家识别出57篇文章。在5岁以下儿童中，AGE住院率总体中位数下降了38%，在儿童死亡率低、中、高的国家分别下降了41%、30%和46%。因轮状病毒AGE导致的住院和急诊就诊总体中位数分别减少了67%，在儿童死亡率低、中、高的国家分别减少了71%、59%和60%。轮状病毒疫苗的实施大幅减少了轮状病毒和全因AGE导致的住院。
