Schmidt R, Kabatzki J, Hartung S, Ackermann R
Dtsch Med Wochenschr. 1985 Nov 22;110(47):1803-7. doi: 10.1055/s-2008-1069091.
A positive antibody titre against Ixodes-ricinus-Borrelia (burgdorferi), using indirect immunofluorescence or ELISA, could be detected in serum and (or) liquor of 935 (32%) out of a total of 2955 patients between January 1984 and July 1985. In 289 of these cases the typical clinical manifestations were lacking whereas a characteristic disease picture enabled a diagnosis to be made in 171 patients with negative or borderline antibody titres. The 1106 cases of infection observed covered all regions of the country. A typical clinical syndrome was seen in 817 (74%) of these. Most common were erythema chronicum migrans (n = 458) and meningopolyneuritis Garin-Bujadoux-Bannwarth (n = 404); in 42% of the cases meningopolyneuritis was preceded by an erythema. Arthritis (n = 63), acrodermatitis chronica atrophicans (n = 72), carditis (n = 13) and lymphadenosis benigna cutis (n = 5) were much less common. Chronic Borrelian encephalomyelitis (n = 45) appeared surprisingly often (n = 45). The fact that in 73% of cases the various syndromes appeared alone, were double in 24% and combined only in 3%, illustrates the polymorphic nature of this disease.
在1984年1月至1985年7月期间，对2955名患者进行检测，结果显示，采用间接免疫荧光法或酶联免疫吸附测定法，在935名（32%）患者的血清和（或）脑脊液中检测到针对蓖麻硬蜱-伯氏疏螺旋体（博氏疏螺旋体）的阳性抗体滴度。在这些病例中，289例缺乏典型临床表现，而171例抗体滴度为阴性或临界值的患者则呈现出特征性疾病表现，从而得以确诊。观察到的1106例感染病例遍布该国所有地区。其中817例（74%）出现典型临床综合征。最常见的是慢性游走性红斑（n = 458）和加林-布雅杜-班瓦特脑膜多神经炎（n = 404）；42%的病例中，脑膜多神经炎之前出现过红斑。关节炎（n = 63）、慢性萎缩性肢端皮炎（n = 72）、心脏炎（n = 13）和良性皮肤淋巴腺病（n = 5）则较为少见。慢性伯氏疏螺旋体脑脊髓炎（n = 45）的出现频率令人惊讶（n = 45）。73%的病例中各种综合征单独出现，24%为双重出现，仅3%为合并出现，这一事实说明了该疾病的多形性。
