Elias-Jones A C, Dhillon S, Greenough A
Early Hum Dev. 1985 Oct;12(1):9-14. doi: 10.1016/0378-3782(85)90131-8.
40 ventilated premature infants, with gestational ages of 24-34 weeks and a mean birthweight of 1422 g, were entered into a randomised controlled trial. 20 of the infants received orally 5 mg/ml anhydrous theophylline dissolved in 20% pure alcohol, with a loading dose of 5 mg/kg and then 1.25 mg/kg every 6 h. Plasma samples were assayed via an emit enzyme immunoassay, demonstrating satisfactory serum levels in all infants at 54 h after the loading dose. Possible side-effects were seen only in two infants, in one a tachycardia (220 beats/min) and the other became agitated during treatment.
40名孕周为24 - 34周、平均出生体重为1422克的机械通气早产儿进入了一项随机对照试验。其中20名婴儿口服溶解于20%纯酒精中的5毫克/毫升无水茶碱，负荷剂量为5毫克/千克，然后每6小时1.25毫克/千克。通过发射酶免疫测定法检测血浆样本，结果显示在负荷剂量后54小时所有婴儿的血清水平均令人满意。仅在两名婴儿身上观察到可能的副作用，一名出现心动过速（220次/分钟），另一名在治疗期间变得烦躁不安。
