酵母基因SIR1、SIR3和SIR4的图谱位置。
Map positions of yeast genes SIR1, SIR3 and SIR4.
作者信息
Ivy J M, Hicks J B, Klar A J
出版信息
Genetics. 1985 Dec;111(4):735-44. doi: 10.1093/genetics/111.4.735.
Abstract
The HML and HMR loci in the yeast Saccharomyces cerevisiae each contain a complete copy of mating-type information. HML and HMR normally are transcriptionally inactive due to four unlinked genes, known as MAR or SIR or CMT. The map position of MAR1 (SIR2) has been reported previously; it is located on the left arm of chromosome IV, 27 cM from the centromere. Using conventional meiotic and mitotic mapping combined with recombinant DNA techniques, we have mapped three other SIR genes. SIR1 maps near the telomere of the right arm of chromosome XI; SIR3 (MAR2) maps to the right arm of chromosome XII, 31 cM distal to URA4; and SIR4 maps to the right arm of chromosome IV, 16 cM proximal to LYS4.
摘要
酵母酿酒酵母中的HML和HMR基因座各自包含一份完整的交配型信息拷贝。由于四个不连锁的基因，即MAR或SIR或CMT，HML和HMR通常处于转录无活性状态。MAR1（SIR2）的图谱位置先前已有报道；它位于第四条染色体的左臂，距着丝粒27厘摩。利用传统的减数分裂和有丝分裂图谱分析结合重组DNA技术，我们已对其他三个SIR基因进行了定位。SIR1定位于第十一条染色体右臂的端粒附近；SIR3（MAR2）定位于第十二条染色体的右臂，距URA4远端31厘摩；SIR4定位于第四条染色体的右臂，距LYS4近端16厘摩。
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