Kibria Fazle, Das Sudip Kumar, Arefin Md Sahidul
Department of Pharmaceutical Science, University of South Florida, Tampa, Florida, USA.
Department of Otolaryngology and ENT Surgery, Kolkata Medical College and Hospital, Kolkata, India.
Kardiochir Torakochirurgia Pol. 2024 Jun;21(2):86-95. doi: 10.5114/kitp.2024.141145. Epub 2024 Jun 30.
The increasing trend of cardiac diseases is becoming a major threat globally. Cardiac activities are based on integrated action potential through electronic flux changes within intra- and extracellular molecular activities. Nicotinamide adenine dinucleotide (NAD) is a major electron carrier present in almost all living cells and creates gated potential by electron exchange from one chemical to another in terms of oxidation (NAD) and reduction (NADH) reactions. NAD plays an important role directly or indirectly in protecting against various cardiovascular diseases, including heart failure, occlusion, ischemia-reperfusion (IR) injury, arrhythmia, myocardial infarction (MI), rhythmic disorder, and a higher order of cardiovascular complexity. Nicotinamide phosphoribosyl transferase (NAMPT) is well known as a rate-limiting enzyme in this pathway except for NAD synthesis and directly involved in the cardioprotective activity. There are two more enzymes - nicotinate phosphoribosyl transferase (NAPRT) and nicotinamide riboside kinase (NRK) - which also work as rate-limiting factors in the NAD+ synthesis pathway. This study concentrated on the role of NAMPT, NAPRT, and NRK in cardioprotective activity and prospective cardiac health.
心脏病发病率不断上升的趋势正成为全球的一大威胁。心脏活动基于细胞内和细胞外分子活动中电子通量变化所产生的综合动作电位。烟酰胺腺嘌呤二核苷酸（NAD）是几乎所有活细胞中存在的主要电子载体，通过氧化（NAD）和还原（NADH）反应，在一种化学物质与另一种化学物质之间进行电子交换，从而产生门控电位。NAD在预防各种心血管疾病方面直接或间接发挥着重要作用，这些疾病包括心力衰竭、血管阻塞、缺血再灌注（IR）损伤、心律失常、心肌梗死（MI）、节律紊乱以及更复杂的心血管疾病。烟酰胺磷酸核糖转移酶（NAMPT）是该途径中除NAD合成外的一种限速酶，并直接参与心脏保护活性。还有另外两种酶——烟酸磷酸核糖转移酶（NAPRT）和烟酰胺核苷激酶（NRK）——它们在NAD+合成途径中也作为限速因子发挥作用。本研究聚焦于NAMPT、NAPRT和NRK在心脏保护活性及潜在心脏健康方面的作用。
