Lee Dae Hyung, Choi Yeji, Lee Mi Hee, Park Jong-Chul
Advanced Medical Device R&D Center, HansBiomed Co., Ltd, Seoul 05836, Republic of Korea.
Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Regen Biomater. 2024 Jun 17;11:rbae069. doi: 10.1093/rb/rbae069. eCollection 2024.
As we age, our skin loses elasticity and wrinkles form. To prevent this, most people try to improve skin wrinkles by performing procedures such as fillers, and absorbable lifting threads. Another way to solve this structural problem is to use an elastic thread. Although elastic sutures made of polymer materials (such as silicone) are widely used, data regarding their properties and potential effectiveness are lacking. This study aimed to investigate the effects of inserting non-absorbable elastic threads, with different manufacturing requirements and methods, on the skin and subcutaneous tissue. In this study, non-absorbable elastic threads ELATENS and Elasticum using different manufacturing methods were compared. Each thread was transplanted into the subcutaneous layer of the back of a rat to induce wrinkles. After inducing wrinkles in the skin of rat, the degree of skin maintenance by each thread and the thickness of the capsule formed around the suture were measured. Through experiments on each thread, the fixation force in the tissue was confirmed. In a comparison of inflammatory response and collagen formation through histological analysis, it was confirmed that there was no significant difference from the equivalent comparative product. In conclusion, the degree of encapsulation between tissues and collagen fiber formation for improving skin wrinkles was superior in elastic threads compared to non-elastic threads. It is believed that this provides certain elasticity to the skin layer and can induce cell influx to improve wrinkles.
随着年龄的增长，我们的皮肤会失去弹性并形成皱纹。为了预防这种情况，大多数人试图通过填充剂和可吸收提拉线等手术来改善皮肤皱纹。解决这个结构问题的另一种方法是使用弹性线。尽管由聚合物材料（如硅胶）制成的弹性缝线被广泛使用，但关于其性能和潜在效果的数据却很缺乏。本研究旨在调查插入具有不同制造要求和方法的不可吸收弹性线对皮肤和皮下组织的影响。在本研究中，比较了使用不同制造方法的不可吸收弹性线ELATENS和Elasticum。将每根线移植到大鼠背部的皮下层以诱导皱纹。在诱导大鼠皮肤出现皱纹后，测量每根线对皮肤的维持程度以及缝线周围形成的包膜厚度。通过对每根线的实验，确认了其在组织中的固定力。通过组织学分析比较炎症反应和胶原蛋白形成，证实与等效的对照产品没有显著差异。总之，与非弹性线相比，弹性线在组织间的包封程度和用于改善皮肤皱纹的胶原纤维形成方面更具优势。据信，这为皮肤层提供了一定的弹性，并可诱导细胞流入以改善皱纹。
