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对……的植物学、植物化学、药理学、合成生物学及综合利用的综述。 你提供的原文似乎不完整，“of”后面缺少具体内容。

A review of the botany, phytochemistry, pharmacology, synthetic biology and comprehensive utilization of .

作者信息

Zhang Xiaozhuang, Liu Meiqi, Wang Zhen, Wang Panpan, Kong Lingyang, Wu Jianhao, Wu Wei, Ma Lengleng, Jiang Shan, Ren Weichao, Du Likun, Ma Wei, Liu Xiubo

机构信息

College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China.

First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.

出版信息

Front Pharmacol. 2024 Jul 11;15:1417655. doi: 10.3389/fphar.2024.1417655. eCollection 2024.

DOI:10.3389/fphar.2024.1417655
PMID:39055491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11269164/
Abstract

(L.) Gaertn, a herbaceous plant with a long history in traditional medicine for the treatment of hepatobiliary diseases, particularly in Europe, which has attracted attention for its remarkable therapeutic effect. This review systematically summarizes the research progress in the botany, phytochemistry, pharmacology, comprehensive utilization and synthetic biology of . . Up to now, more than 20 types of flavonolignan components have been isolated from . . In addition, the rearch on fatty acids and triterpenoids is also constantly improving. Among them, silybin is the most active compound in flavonolignans components. Its pharmacological effects and include anti-inflammatory, antioxidant, anti-tumour, hypoglycaemic, neuroprotective and immunoregulatory properties. The use of coniferyl alcohol and taxifolin as substrates to produce silybin and isosilybin under the action of enzyme catalysis is the commonly used biosynthetic pathway of silymarin, which provides support for a comprehensive analysis of the synthetic pathway of silymarin. In addition to medicinal use, the extracts of plants also have broad application prospects in the production of food, healthcare products, cosmetics and other aspects. In addition, the chemical composition, pharmacological mechanism and synthetic biology of need to be further studied, which is very important for its clinical efficacy and resource development.

摘要

(L.) Gaertn是一种在传统医学中用于治疗肝胆疾病历史悠久的草本植物，尤其在欧洲，因其显著的治疗效果而备受关注。本综述系统总结了……在植物学、植物化学、药理学、综合利用及合成生物学方面的研究进展。截至目前，已从……中分离出20多种黄酮木脂素成分。此外，对脂肪酸和三萜类化合物的研究也在不断完善。其中，水飞蓟宾是黄酮木脂素成分中活性最强的化合物。其药理作用包括抗炎、抗氧化、抗肿瘤、降血糖、神经保护和免疫调节特性。以松柏醇和紫杉叶素为底物，在酶催化作用下生产水飞蓟宾和异水飞蓟宾是水飞蓟素常用的生物合成途径，这为全面解析水飞蓟素的合成途径提供了支持。除药用外，该植物提取物在食品、保健品、化妆品等生产方面也具有广阔的应用前景。此外，……的化学成分、药理机制及合成生物学仍需进一步研究，这对其临床疗效及资源开发具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/d32c990a1ba3/fphar-15-1417655-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/aea483baf856/fphar-15-1417655-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/d09174edc510/fphar-15-1417655-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/2821bbc6f439/fphar-15-1417655-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/c34a201a312d/fphar-15-1417655-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/47d5d7377159/fphar-15-1417655-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/862b72c0019a/fphar-15-1417655-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/0d16e093f88f/fphar-15-1417655-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/7da7aa8e9f7a/fphar-15-1417655-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/d32c990a1ba3/fphar-15-1417655-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/aea483baf856/fphar-15-1417655-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/d09174edc510/fphar-15-1417655-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/2821bbc6f439/fphar-15-1417655-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/c34a201a312d/fphar-15-1417655-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/47d5d7377159/fphar-15-1417655-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/862b72c0019a/fphar-15-1417655-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/0d16e093f88f/fphar-15-1417655-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/7da7aa8e9f7a/fphar-15-1417655-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9890/11269164/d32c990a1ba3/fphar-15-1417655-g009.jpg

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