Lin Xiuying, Fang Yanqiu, Mi Xuguang, Fu Jianhua, Chen Shiling, Wu Mengxue, Jin Ningyi
Medical College, Yanbian University, Yanji, China.
Reproductive Medicine Center, Jilin Province People's Hospital, Changchun, China.
Heliyon. 2024 Jul 3;10(13):e34047. doi: 10.1016/j.heliyon.2024.e34047. eCollection 2024 Jul 15.
Cervical cancer (CC) is a malignant tumor of the female reproductive system that typically occurs in cervical cells and has high incidence and mortality rates, strong metastatic ability, and poor prognosis. Asiatic acid (AA) exhibits anti-inflammatory, anti-depressant, and anti-tumor effects. However, the molecular targets and mechanisms underlying AA-mediated inhibition of CC metastasis remain unclear. AA affects the proliferation, metastasis, and epithelial-mesenchymal transition (EMT) process of CC cell lines. MTT experiments verified that AA inhibited the proliferation ability of CC cells, and the effect of AA on the lateral and longitudinal migration ability of CC was evaluated through wound healing and Transwell assays. Western blotting was used to explore whether AA inhibits EMT process in HeLa and C33a cells. Currently, targeting the PI3K/AKT/mTOR pathway as a strategy for cancer treatment remains an evolving field. However, the molecular mechanism by which AA inhibits CC via the PI3K/AKT/mTOR pathway remains unclear and requires further investigation.
宫颈癌（CC）是女性生殖系统的一种恶性肿瘤，通常发生在宫颈细胞中，具有高发病率和死亡率、强转移能力以及较差的预后。齐墩果酸（AA）具有抗炎、抗抑郁和抗肿瘤作用。然而，AA介导抑制CC转移的分子靶点和机制仍不清楚。AA影响CC细胞系的增殖、转移和上皮-间质转化（EMT）过程。MTT实验证实AA抑制CC细胞的增殖能力，并通过伤口愈合实验和Transwell实验评估AA对CC横向和纵向迁移能力的影响。采用蛋白质免疫印迹法探讨AA是否抑制HeLa和C33a细胞中的EMT过程。目前，靶向PI3K/AKT/mTOR通路作为癌症治疗策略仍是一个不断发展的领域。然而，AA通过PI3K/AKT/mTOR通路抑制CC的分子机制仍不清楚，需要进一步研究。
