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温水浸泡对糖尿病大鼠肾组织损伤的长期影响。

Long-term effects of warm water immersion on kidney tissue damage in diabetic rats.

作者信息

Jozi Faezeh, Kheiripour Nejat, Akhavan Taheri Maryam, Ghavipanjeh Gholamreza, Nasehi Zahra, Esmaeil Shahaboddin Mohammad

机构信息

Institute for Basic Sciences, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences.

Kashan, Iran.

出版信息

Iran J Basic Med Sci. 2024;27(9):1162-1171. doi: 10.22038/IJBMS.2024.74307.16141.

DOI:10.22038/IJBMS.2024.74307.16141
PMID:39055872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11266743/
Abstract

OBJECTIVES

This study aimed to investigate the effects of Warm Water Immersion (WWI) on inflammation, kidney function, and kidney tissue damage in rats with diabetes mellitus (DM).

MATERIALS AND METHODS

Forty male rats were divided into four groups: Healthy Control (HC), Diabetic Control (DC), Diabetic Rats treated with WWI (DW), and Healthy Rats treated with WWI (HW). Daily 15-minute WWI sessions at 43 °C were administered for eight weeks. Various parameters including lipids, fasting blood sugar (FBS), HbA1C, insulin, advanced glycation end products (AGEs), HSP70, glomerular filtration rate (GFR), urinary albumin excretion, creatinine, blood urea nitrogen (BUN), oxidative stress, anti-oxidant parameters, and gene expression of RAGE, VEGF, and TGFß1 were assessed. Histological examination of kidney tissue was also conducted.

RESULTS

Significant reductions in FBS, AGEs, glutathione, superoxide dismutase (SOD), and nitric oxide (NO) levels were observed in the DW group compared to DC. Expression of RAGE, VEGF, and TGFß1 genes decreased in DW. Triglycerides, total cholesterol, and LDL cholesterol were lower in DW. Insulin, HDL cholesterol, catalase, total anti-oxidant capacity (TAC), and tissue HSP70 were higher in DW. Histological assessment revealed reduced kidney damage in DW compared to DC.

CONCLUSION

WWI for eight weeks shows promise in mitigating diabetic nephropathy in rats, suggesting its potential as a non-invasive adjunctive therapy for managing diabetes complications.

摘要

目的

本研究旨在探讨温水浸泡（WWI）对糖尿病（DM）大鼠炎症、肾功能及肾组织损伤的影响。

材料与方法

40只雄性大鼠分为四组：健康对照组（HC）、糖尿病对照组（DC）、接受WWI治疗的糖尿病大鼠（DW）和接受WWI治疗的健康大鼠（HW）。每天在43℃下进行15分钟的WWI，持续8周。评估了包括血脂、空腹血糖（FBS）、糖化血红蛋白（HbA1C）、胰岛素、晚期糖基化终产物（AGEs）、热休克蛋白70（HSP70）、肾小球滤过率（GFR）、尿白蛋白排泄、肌酐、血尿素氮（BUN）、氧化应激、抗氧化参数以及RAGE、VEGF和TGFβ1的基因表达等各种参数。还对肾组织进行了组织学检查。

结果

与DC组相比，DW组的FBS、AGEs、谷胱甘肽、超氧化物歧化酶（SOD）和一氧化氮（NO）水平显著降低。DW组中RAGE、VEGF和TGFβ1基因的表达下降。DW组的甘油三酯、总胆固醇和低密度脂蛋白胆固醇较低。DW组的胰岛素、高密度脂蛋白胆固醇、过氧化氢酶、总抗氧化能力（TAC）和组织HSP70较高。组织学评估显示，与DC组相比，DW组的肾损伤减轻。

结论

8周的WWI有望减轻大鼠糖尿病肾病，表明其作为管理糖尿病并发症的非侵入性辅助治疗方法的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/e716f6782551/IJBMS-27-1162-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/8a73b8f37526/IJBMS-27-1162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/d892d8697f5d/IJBMS-27-1162-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/87e1f9ac13db/IJBMS-27-1162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/0efe7fb0dc04/IJBMS-27-1162-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/f1df5467f473/IJBMS-27-1162-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/7abf935d9b2e/IJBMS-27-1162-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/e716f6782551/IJBMS-27-1162-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/8a73b8f37526/IJBMS-27-1162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/d892d8697f5d/IJBMS-27-1162-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/87e1f9ac13db/IJBMS-27-1162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/0efe7fb0dc04/IJBMS-27-1162-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/f1df5467f473/IJBMS-27-1162-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/7abf935d9b2e/IJBMS-27-1162-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e1b/11266743/e716f6782551/IJBMS-27-1162-g007.jpg

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