Yu Silai, Jiang Shanshan, Zhou Yue, Zhu Zhengfei, Yang Xi
Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Adv Radiat Oncol. 2024 Jul 4;9(8):101549. doi: 10.1016/j.adro.2024.101549. eCollection 2024 Aug.
Exosomes have been shown to play a role in most, if not all, steps of cancer progression. We still lack a comprehensive understanding of the bidirectional communication of exosomes between tumor cells and immune cells. This article aims to explore how exosomes can influence cancer growth and how they are affected by radiation therapy.
We searched on PubMed and Web of Science on the impact of radiation on tumor derived exosomes and immune cell derived exosomes in tumor immune microenvironment. We screened all the related articles and summarized their main discoveries and important results.
This article reviewed the effects of tumor derived exosomes and immune cell-derived exosomes on TME and tumor progression after radiotherapy, suggesting the dual effects of exosomes which may refer to clinical practice. Moreover, we retrospected the clinical applications based on tumor derived exosomes, including liquid biopsy, radio-resistance and drug delivery, and discussed the challenges and prospects.
Exosomes are important in cancer treatment, especially with radiation therapy. Learning more about them could lead to better treatments. However, there are still challenges to overcome. The review points out the need for more research in this area.
已表明外泌体在癌症进展的大多数（即便不是全部）步骤中发挥作用。我们仍缺乏对外泌体在肿瘤细胞与免疫细胞之间双向通讯的全面理解。本文旨在探讨外泌体如何影响癌症生长以及它们如何受到放射治疗的影响。
我们在PubMed和科学网搜索了辐射对肿瘤免疫微环境中肿瘤来源外泌体和免疫细胞来源外泌体的影响。我们筛选了所有相关文章并总结了它们的主要发现和重要结果。
本文综述了放疗后肿瘤来源外泌体和免疫细胞来源外泌体对肿瘤微环境和肿瘤进展的影响，提示外泌体的双重作用可能对临床实践有参考价值。此外，我们回顾了基于肿瘤来源外泌体的临床应用，包括液体活检、放射抗性和药物递送，并讨论了挑战和前景。
外泌体在癌症治疗中很重要，尤其是在放射治疗方面。更多地了解它们可能会带来更好的治疗方法。然而，仍有挑战需要克服。该综述指出了在这一领域进行更多研究的必要性。
