Todaro Mattia, Saponaro Gianmarco, Perquoti Federico, Gasparini Giulio, Signorelli Francesco, Tartaglione Tommaso, Moro Alessandro
Maxillo Facial Surgery Unit, Fondazione Policlinico Agostino Gemelli IRCCS Hospital, 8 Largo Agostino Gemelli, 00168 Rome, Italy.
Neurosurgery Unit, Fondazione Policlinico Agostino Gemelli IRCCS Hospital, 8 Largo Agostino Gemelli, 00168 Rome, Italy.
Biology (Basel). 2024 Jun 25;13(7):467. doi: 10.3390/biology13070467.
Polyetheretherketone (PEEK) in the last few years has emerged as an exceedingly promising material for craniofacial defects due to its biocompatibility and mechanical properties. However, its utilization remains controversial due to its inertness and low osteoinductivity. This study aimed to investigate the postoperative outcomes of patients undergoing maxillo-facial and neurosurgical procedures with PEEK implants. The focus is on evaluating bone regrowth on the surface and edges of the implant, periosteal reactions, and implant positioning. A retrospective analysis of 12 maxillo-facial surgery patients and 10 neurosurgery patients who received PEEK implants was conducted. CT scans performed at least one year post operation were examined for bone regrowth, periosteal reactions, and implant positioning. In maxillo-facial cases, the analysis included mandibular angle and fronto-orbital reconstruction, while neurosurgical cases involved cranioplasty. In maxillofacial surgery, 11 out of 12 patients showed radiological evidence of bone regrowth around PEEK implants, with favorable outcomes observed in craniofacial reconstruction. In neurosurgery, 9 out of 10 patients exhibited minimal or none bone regrowth, while one case demonstrated notable bone regeneration beneath the PEEK implant interface. The study highlights the importance of implant design and patient-specific factors in achieving successful outcomes, providing valuable insights for future implant-based procedures.
聚醚醚酮（PEEK）在过去几年中因其生物相容性和机械性能，已成为一种极具前景的用于颅面缺损修复的材料。然而，由于其惰性和低骨诱导性，其应用仍存在争议。本研究旨在调查接受PEEK植入物的颌面和神经外科手术患者的术后结果。重点是评估植入物表面和边缘的骨再生、骨膜反应以及植入物位置。对12例接受PEEK植入物的颌面外科手术患者和10例神经外科手术患者进行了回顾性分析。检查术后至少一年进行的CT扫描，以评估骨再生、骨膜反应和植入物位置。在颌面病例中，分析包括下颌角和额眶重建，而神经外科病例涉及颅骨成形术。在颌面外科手术中，12例患者中有11例显示PEEK植入物周围有骨再生的影像学证据，在颅面重建中观察到良好的结果。在神经外科手术中，10例患者中有9例骨再生极少或没有，而1例在PEEK植入物界面下方显示出明显的骨再生。该研究强调了植入物设计和患者个体因素对实现成功结果的重要性，为未来基于植入物的手术提供了有价值的见解。
