Chu Natural H S, Chow Elaine, Chan Juliana C N
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.
Biology (Basel). 2024 Jul 4;13(7):498. doi: 10.3390/biology13070498.
Exploring the intricate crosstalk between dietary prebiotics and the specific intestinal microbiome (SIM) is intriguing in explaining the mechanisms of current successful dietary interventions, including the Mediterranean diet and high-fiber diet. This knowledge forms a robust basis for developing a new natural food therapy. The SIM diet can be measured and evaluated to establish a reliable basis for the management of metabolic diseases, such as diabetes, metabolic (dysfunction)-associated fatty liver disease (MAFLD), obesity, and metabolic cardiovascular disease. This review aims to delve into the existing body of research to shed light on the promising developments of possible dietary prebiotics in this field and explore the implications for clinical practice. The exciting part is the crosstalk of diet, microbiota, and gut-organ interactions facilitated by producing short-chain fatty acids, bile acids, and subsequent metabolite production. These metabolic-related microorganisms include , , and The SIM diet, rather than supplementation, holds the promise of significant health consequences via the prolonged reaction with the gut microbiome. Most importantly, the literature consistently reports no adverse effects, providing a strong foundation for the safety of this dietary therapy.
探索膳食益生元与特定肠道微生物群（SIM）之间复杂的相互作用，对于解释当前成功的膳食干预机制（包括地中海饮食和高纤维饮食）具有重要意义。这一知识为开发新的天然食物疗法奠定了坚实基础。SIM饮食可以进行测量和评估，从而为糖尿病、代谢（功能障碍）相关脂肪性肝病（MAFLD）、肥胖症和代谢性心血管疾病等代谢性疾病的管理建立可靠依据。本综述旨在深入研究现有研究成果，以揭示该领域中膳食益生元可能的有前景的发展，并探讨其对临床实践的影响。令人兴奋的是，通过产生短链脂肪酸、胆汁酸以及随后的代谢产物生成，饮食、微生物群和肠道 - 器官相互作用之间存在相互影响。这些与代谢相关的微生物包括……（原文此处未完整列出微生物名称）。SIM饮食而非补充剂，通过与肠道微生物群的长期相互作用，有望对健康产生重大影响。最重要的是，文献一致报道无不良影响，为这种饮食疗法的安全性提供了有力依据。
