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移植性腺移植物的低存活率：冷冻保存和移植条件对线粒体功能的影响

The Low Survivability of Transplanted Gonadal Grafts: The Impact of Cryopreservation and Transplantation Conditions on Mitochondrial Function.

作者信息

Moniz Inês, Soares Maria, Sousa Ana Paula, Ramalho-Santos João, Branco Ana

机构信息

Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal.

CNC-Centre for Neuroscience and Cell Biology, CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Azinhaga de Santa Comba, Polo 3, 3000-548 Coimbra, Portugal.

出版信息

Biology (Basel). 2024 Jul 18;13(7):542. doi: 10.3390/biology13070542.

DOI:10.3390/biology13070542
PMID:39056734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274302/
Abstract

Advances in tissue preservation techniques have allowed reproductive medicine and assisted reproductive technologies (ARTs) to flourish in recent years. Because radio- and chemotherapy procedures are often gonadotoxic, irreversible damage can preclude future gamete production and endocrine support. Accordingly, in recent years, the freezing and storage of gonadal tissue fragments prior to the first oncological treatment appointment and autologous transplantation post-recovery have been considered improved solutions for fertility recovery in cancer survivors. Nevertheless, the cryopreservation and transplantation of thawed tissues is still very limited, and positive outcomes are relatively low. This review aims to discuss the limitations of oncofertility protocols with a focus on the impacts of mitochondrial dysfunction, oxidative stress, and the loss of antioxidant defense in graft integrity.

摘要

近年来，组织保存技术的进步使生殖医学和辅助生殖技术（ARTs）蓬勃发展。由于放疗和化疗程序通常具有性腺毒性，不可逆转的损伤可能会妨碍未来的配子生成和内分泌支持。因此，近年来，在首次肿瘤治疗预约前冷冻保存性腺组织碎片以及康复后进行自体移植，被认为是癌症幸存者恢复生育能力的改良解决方案。然而，解冻组织的冷冻保存和移植仍然非常有限，积极结果相对较少。本综述旨在讨论肿瘤生育方案的局限性，重点关注线粒体功能障碍、氧化应激以及抗氧化防御丧失对移植物完整性的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e15/11274302/ea36ec309204/biology-13-00542-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e15/11274302/9c452a94aafd/biology-13-00542-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e15/11274302/94d0ef929cbe/biology-13-00542-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e15/11274302/e3bcfc82e820/biology-13-00542-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e15/11274302/ea36ec309204/biology-13-00542-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e15/11274302/9c452a94aafd/biology-13-00542-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e15/11274302/94d0ef929cbe/biology-13-00542-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e15/11274302/e3bcfc82e820/biology-13-00542-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e15/11274302/ea36ec309204/biology-13-00542-g004.jpg

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本文引用的文献

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Systematic review and meta-analysis on patented and non-patented vitrification processes to ovarian tissue reported between 2000 and 2021.2000年至2021年间关于专利和非专利卵巢组织玻璃化冷冻方法的系统评价和荟萃分析。
Anim Reprod. 2023 Nov 10;20(3):e20230065. doi: 10.1590/1984-3143-AR2023-0065. eCollection 2023.
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ART in Europe, 2019: results generated from European registries by ESHRE†.ART 在欧洲，2019：ESHRE 通过欧洲注册中心生成的结果。
Hum Reprod. 2023 Dec 4;38(12):2321-2338. doi: 10.1093/humrep/dead197.
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Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model.
卵巢冷冻保存和自体移植对小鼠模型中卵巢移植物和所产生卵母细胞质量的不良影响。
Clin Sci (Lond). 2023 Oct 31;137(20):1577-1591. doi: 10.1042/CS20230483.
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Advances in the mechanisms related to follicle loss after frozen-thawed ovarian tissue transplantation.冻融卵巢组织移植后卵泡丢失相关机制的研究进展
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The mTOR Inhibitor Rapamycin Counteracts Follicle Activation Induced by Ovarian Cryopreservation in Murine Transplantation Models.雷帕霉素（mTOR 抑制剂）可拮抗卵巢冷冻保存诱导的小鼠移植模型中的卵泡激活。
Medicina (Kaunas). 2023 Aug 16;59(8):1474. doi: 10.3390/medicina59081474.
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Roles of follicle stimulating hormone and sphingosine 1-phosphate co-administered in the process in mouse ovarian vitrification and transplantation.卵泡刺激素和鞘氨醇 1-磷酸联合作用在小鼠卵巢玻璃化和移植过程中的作用。
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Effects of pulsed electromagnetic fields and N-acetylcysteine on transplantation of vitrified mouse ovarian tissue.脉冲电磁场和 N-乙酰半胱氨酸对玻璃化小鼠卵巢组织移植的影响。
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