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叉头转录因子Fd59a在……精子发生中的功能分析 。（原文中“of”后面缺少具体物种等信息）

Functional Analysis of Forkhead Transcription Factor Fd59a in the Spermatogenesis of .

作者信息

Tang Ting, Pei Mengyuan, Xiao Yanhong, Deng Yingshan, Lu Yuzhen, Yu Xiao-Qiang, Wen Liang, Hu Qihao

机构信息

Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou 510631, China.

National Key Laboratory of Green Pesticide, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China.

出版信息

Insects. 2024 Jun 27;15(7):480. doi: 10.3390/insects15070480.

DOI:10.3390/insects15070480
PMID:39057213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11277555/
Abstract

Spermatogenesis is critical for insect reproduction and is regulated by many different genes. In this study, we found that Forkhead transcription factor Fd59a functions as a key factor in the spermatogenesis of . Fd59a contains a conversed Forkhead domain, and it is clustered to the FoxD subfamily with other FoxD members from some insect and vertebrate species. Mutations in caused swelling in the apical region of the testis. More importantly, fewer mature sperm were present in the seminal vesicle of mutant flies compared to the control flies, and the fertility of mutant males was significantly lower than that of the control flies. Immunofluorescence staining showed that the homeostasis of the testis stem cell niche in mutant and RNAi flies was disrupted and the apoptosis of sperm bundles was increased. Furthermore, results from RNA sequencing and qRT-PCR suggested that Fd59a can regulate the expression of genes related to reproductive process and cell death. Taken together, our results indicated that Fd59a plays a key role in the spermatogenesis of .

摘要

精子发生对于昆虫繁殖至关重要，且受许多不同基因调控。在本研究中，我们发现叉头转录因子Fd59a在[昆虫名称]的精子发生中起关键作用。Fd59a含有一个保守的叉头结构域，并且与来自一些昆虫和脊椎动物物种的其他FoxD成员聚集在FoxD亚家族中。[昆虫名称]的突变导致睾丸顶端区域肿胀。更重要的是，与对照果蝇相比，[昆虫名称]突变果蝇的精囊中成熟精子数量更少，且突变雄性果蝇的生育力显著低于对照果蝇。免疫荧光染色显示，[昆虫名称]突变体和[昆虫名称]RNA干扰果蝇的睾丸干细胞微环境稳态被破坏，精子束的凋亡增加。此外，RNA测序和qRT-PCR结果表明，Fd59a可调节与生殖过程和细胞死亡相关的基因表达。综上所述，我们的结果表明Fd59a在[昆虫名称]的精子发生中起关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/abf042a879f8/insects-15-00480-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/6cab0bbb6662/insects-15-00480-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/22ccb743899e/insects-15-00480-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/50e6ee871a0b/insects-15-00480-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/27ced791985b/insects-15-00480-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/13d496fbd47f/insects-15-00480-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/abf042a879f8/insects-15-00480-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/6cab0bbb6662/insects-15-00480-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/22ccb743899e/insects-15-00480-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/50e6ee871a0b/insects-15-00480-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/27ced791985b/insects-15-00480-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/13d496fbd47f/insects-15-00480-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5c/11277555/abf042a879f8/insects-15-00480-g006.jpg

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本文引用的文献

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J Pers Med. 2023 Mar 15;13(3):530. doi: 10.3390/jpm13030530.
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Is Required for Spermatogenesis of .对于 的精子发生是必需的。
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MicroRNAs as the Critical Regulators of Forkhead Box Protein Family in Pancreatic, Thyroid, and Liver Cancers.微小 RNA 作为胰腺、甲状腺和肝癌中叉头框蛋白家族的关键调控因子。
Biochem Genet. 2023 Oct;61(5):1645-1674. doi: 10.1007/s10528-023-10346-4. Epub 2023 Feb 13.
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