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一种增强型氧化锌丁香酚与Cloisite 5A纳米粘土结合物的抗菌性能：一项体外研究。

The Antibacterial Properties of a Reinforced Zinc Oxide Eugenol Combined with Cloisite 5A Nanoclay: An In-Vitro Study.

作者信息

Nazemisalman Bahareh, Niaz Shaghayegh, Darvish Shayan, Notash Ayda, Ramazani Ali, Luchian Ionut

机构信息

Department of Pediatric Dentistry, School of Dentistry, Zanjan University of Medical Sciences, Zanjan 4513956184, Iran.

Independent Researcher, Urmia 5719175546, Iran.

出版信息

J Funct Biomater. 2024 Jul 20;15(7):198. doi: 10.3390/jfb15070198.

DOI:10.3390/jfb15070198
PMID:39057319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11278227/
Abstract

Pulpotomies and pulpectomies are the most common clinical approach for dental caries in the primary dentition. Reinforced zinc oxide eugenol (ZOE) is an ideal material for filling in the pulp chamber after pulp therapies. The aim of this study was to assess the addition of Cloisite 5A nanoclay material to ZOE and evaluate its antibacterial properties. In this case-control study, the nanoclay nanoparticles were dissolved using a solvent (Eugenol) in different concentrations and their antibacterial properties were assessed using the agar diffusion test and biofilm analysis of (), (), and () in in vitro conditions using the AATCC 100 standards. The diameter of the inhibition zone was measured and assessed statistically using the SPSS software (Version 28, IBM, Chicago, IL, USA) with a significance level of 0.05. The antibacterial properties of the ZOE with nanoclay particles were significantly greater in comparison to the plain ZOE against , , and . The inhibition zone against under the effect of the ZOE and nanoclay particles combined was significantly higher than that against and . The current study showed that the addition of Cloisite 5A nanoclay particles can improve the antibacterial properties of ZOE significantly at certain concentrations.

摘要

活髓切断术和牙髓摘除术是乳牙龋齿最常见的临床治疗方法。增强型氧化锌丁香酚（ZOE）是牙髓治疗后填充牙髓腔的理想材料。本研究的目的是评估向ZOE中添加Cloisite 5A纳米粘土材料并评估其抗菌性能。在这项病例对照研究中，使用溶剂（丁香酚）以不同浓度溶解纳米粘土纳米颗粒，并使用琼脂扩散试验和生物膜分析，依据美国纺织化学家和染色家协会（AATCC）100标准在体外条件下评估其对（）、（）和（）的抗菌性能。测量抑菌圈直径，并使用SPSS软件（版本28，IBM，美国伊利诺伊州芝加哥）进行统计评估，显著性水平为0.05。与普通ZOE相比，含有纳米粘土颗粒的ZOE对（）、（）和（）的抗菌性能显著更强。ZOE和纳米粘土颗粒联合作用下对（）的抑菌圈显著高于对（）和（）的抑菌圈。当前研究表明，添加Cloisite 5A纳米粘土颗粒在一定浓度下可显著提高ZOE的抗菌性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/5d91c35f968d/jfb-15-00198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/0e095f517da8/jfb-15-00198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/8b91da8a7af8/jfb-15-00198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/099956275919/jfb-15-00198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/556a0c47edcd/jfb-15-00198-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/5d91c35f968d/jfb-15-00198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/0e095f517da8/jfb-15-00198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/8b91da8a7af8/jfb-15-00198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/099956275919/jfb-15-00198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/556a0c47edcd/jfb-15-00198-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16af/11278227/5d91c35f968d/jfb-15-00198-g005.jpg

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