Bai Yanyu, Wang Shenyuan, Wu Kaifeng, Zhang Ming, Alatan Suhe, Cang Ming, Cao Guifang, Jin Hai, Li Changqing, Tong Bin
The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010020, China.
Inner Mongolia Key Laboratory of Biomanufacture, College of Life Sciences, Inner Mongolia Agriculture University, Hohhot 010020, China.
Vet Sci. 2024 Jul 1;11(7):297. doi: 10.3390/vetsci11070297.
The significant deposition of tail fat in sheep has a profound impact on the economic benefits of animal husbandry. Furthermore, increasing the litter size is a crucial means of enhancing economic benefits. The and / genes are considered major functional genes that could affect sheep litter size and tail bone number, respectively. In this study, we employed direct sequencing to identify specific mutations of the gene in Gobi short tail sheep and carried out genotyping using MassARRAY technology for each variant of both the and genes. Significant associations were demonstrated between the c.687G>A mutation of and the litter size in both the Gobi short tail sheep and Ujimqin sheep breeds. Meanwhile, the g.30058882_30058873GCAGATTAAAIndel mutation was significantly associated with the litter size in Gobi short tail sheep. These findings may provide valuable genetic markers for expanding sheep litter size. In addition, we also confirmed that the frequency of tail-bone-number-related T alleles was significantly higher in Gobi short tail sheep than in longer-tailed Ujimqin sheep.
绵羊尾部脂肪的大量沉积对畜牧业的经济效益有着深远影响。此外，增加产羔数是提高经济效益的关键手段。 和 / 基因分别被认为是可能影响绵羊产羔数和尾椎骨数的主要功能基因。在本研究中，我们采用直接测序法鉴定戈壁短尾羊中 基因的特定突变，并使用MassARRAY技术对 和 基因的每个变体进行基因分型。结果表明， 基因的c.687G>A突变与戈壁短尾羊和乌珠穆沁羊的产羔数均显著相关。同时，g.30058882_30058873GCAGATTAAAIndel突变与戈壁短尾羊的产羔数显著相关。这些发现可能为扩大绵羊产羔数提供有价值的遗传标记。此外，我们还证实，与尾椎骨数相关的T等位基因在戈壁短尾羊中的频率显著高于长尾的乌珠穆沁羊。
