Parasin Nichapa, Amnuaylojaroen Teerachai, Saokaew Surasak
School of Allied Health Science, University of Phayao, Phayao 56000, Thailand.
School of Energy and Environment, University of Phayao, Phayao 56000, Thailand.
Toxics. 2024 Jun 21;12(7):446. doi: 10.3390/toxics12070446.
Exposure to PM while pregnant is associated with negative effects on low birth weight (LBW). This study employed a systematic review and meta-analysis to investigate the impact of PM exposure during pregnancy on LBW. A search of databases such as Scopus, ScienceDirect, and PubMed identified thirteen appropriate studies. This study used a random-effects model to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs) for each trimester. The findings revealed a significant relationship between PM exposure and LBW in both the first and second trimesters (OR 1.05, 95% CI 1.00-1.09, < 0.001). There was no significant difference between trimesters ( = 0.704). The results emphasize the persistent influence of PM on fetal development throughout all stages of pregnancy. Reducing air pollution is critical for improving pregnancy outcomes and decreasing the incidence of LBW. Further study is needed to improve exposure assessments and investigate the underlying biological pathways.
孕期接触细颗粒物（PM）与低出生体重（LBW）的负面影响有关。本研究采用系统评价和荟萃分析来调查孕期接触PM对低出生体重的影响。检索Scopus、ScienceDirect和PubMed等数据库后，确定了13项合适的研究。本研究使用随机效应模型计算每个孕期的合并比值比（OR）和95%置信区间（CI）。研究结果显示，在孕早期和孕中期，PM暴露与低出生体重之间均存在显著关联（OR 1.05，95% CI 1.00 - 1.09，< 0.001）。各孕期之间无显著差异（P = 0.704）。结果强调了PM在整个孕期对胎儿发育的持续影响。减少空气污染对于改善妊娠结局和降低低出生体重的发生率至关重要。需要进一步研究以改进暴露评估并调查潜在的生物学途径。
