Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, 610041 Chengdu, China.
Department of Pediatric Surgery, West China Hospital, Sichuan University, 610041 Chengdu, China.
J Mater Chem B. 2024 Aug 28;12(34):8235-8266. doi: 10.1039/d4tb00768a.
In recent years, metal-organic frameworks (MOFs) have garnered widespread attention due to their distinctive attributes, such as high surface area, tunable properties, biodegradability, extremely low density, high loading capacity, diverse chemical functionalities, thermal stability, well-defined pore sizes, and molecular dimensions. Increasingly, biomedical researchers have turned their focus towards their multifaceted development. Among these, stimuli-responsive MOFs, with their unique advantages, have captured greater interest from researchers. This review will delve into the merits and drawbacks of both endogenous and exogenous stimuli-responsive MOFs, along with their application directions. Furthermore, it will outline the characteristics of different synthesis routes of MOFs, exploring various design schemes and modification strategies and their impacts on the properties of MOF products, as well as how to control them. Additionally, we will survey different types of stimuli-responsive MOFs, discussing the significance of various MOF products reported in biomedical applications. We will categorically summarize different strategies such as anticancer therapy, antibacterial treatment, tissue repair, and biomedical imaging, as well as insights into the development of novel MOFs nanomaterials in the future. Finally, this review will conclude by summarizing the challenges in the development of stimuli-responsive MOFs in the field of biomedicine and providing prospects for future research endeavors.
近年来，金属-有机骨架（MOFs）因其独特的属性而受到广泛关注，例如高比表面积、可调性质、可生物降解性、极低密度、高负载能力、多样的化学功能、热稳定性、明确的孔径和分子尺寸。越来越多的生物医学研究人员将注意力转向它们的多方面发展。在这些研究中，具有独特优势的刺激响应型 MOFs 引起了研究人员更大的兴趣。本综述将深入探讨内源性和外源性刺激响应型 MOFs 的优缺点及其应用方向。此外，还将概述 MOFs 的不同合成途径的特点，探讨各种设计方案和改性策略及其对 MOF 产品性能的影响以及如何控制它们。此外，我们还将调查不同类型的刺激响应型 MOFs，讨论在生物医学应用中报告的各种 MOF 产品的意义。我们将分类总结不同的策略，如抗癌治疗、抗菌处理、组织修复和生物医学成像，以及对未来新型 MOFs 纳米材料发展的见解。最后，本综述将总结生物医学领域刺激响应型 MOFs 发展面临的挑战，并为未来的研究工作提供展望。
