华氏巨球蛋白血症中的葡萄膜渗漏
Uveal effusion in Waldenstrom's macroglobulinemia.
作者信息
Darmon Johanna, Anjou Mickael, Georgelin Denis, Brezin Antoine P, Bremond-Gignac Dominique
机构信息
Department of Ophthalmology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
Department of Ophthalmology, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Paris, France.
出版信息
Retin Cases Brief Rep. 2024 Jul 19;19(5):612-4. doi: 10.1097/ICB.0000000000001631.
PURPOSE
To reastport a case of Waldenstrom macroglobulinemia-related choroidal detachments.
METHOD
Case report.
RESULTS
A 80-year-old woman was referred for bilateral visual loss for few months. She was hospitalized for a Waldenstrom's disease. Both anterior chambers were deep and quiet. Fundus revealed bilateral choroidal detachment without serous retinal detachments. No vitritis, retinal tear or pigmented lesion were observed. After eliminating all other causes of uveal effusion, the patient was treated for her hemopathy with chemotherapy associated with corticosteroids and plasmapheresis. One month later, fundus showed a complete disappearance of choroidal detachments and vision improved.
CONCLUSION
Uveal effusion is an extremely rare ocular damage of Waldenström disease. As choroidal vessels are porous, they may allow immunoglobulins, over produced, to leak toward supra-choroidal space triggering choroidal detachments.
目的
报告1例与华氏巨球蛋白血症相关的脉络膜脱离病例。
方法
病例报告。
结果
一名80岁女性因双眼视力丧失数月前来就诊。她因华氏病住院。双眼前房深且安静。眼底检查发现双侧脉络膜脱离，无浆液性视网膜脱离。未观察到葡萄膜炎、视网膜裂孔或色素性病变。在排除所有其他葡萄膜渗漏的原因后，患者接受了化疗联合皮质类固醇和血浆置换治疗血液病。1个月后，眼底检查显示脉络膜脱离完全消失，视力改善。
结论
葡萄膜渗漏是华氏病极其罕见的眼部损害。由于脉络膜血管多孔，可能会使过量产生的免疫球蛋白渗漏至脉络膜上腔，从而引发脉络膜脱离。
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